Infectie De temperatuur beïnvloedt het fenotype en functie van chimere  Antigeen  Receptor  T-cellen geproduceerd  by way of  Lentiviral Expertise

Chimere antigeenreceptor (CAR)-T-celtherapie is een belangrijke methode geworden voor de behandeling van hematologische tumoren. Lentivirussen zijn veelgebruikte genoverdrachtsvectoren voor het bereiden van CAR-T-cellen, en de voorwaarden voor het bereiden van CAR-T-cellen variëren sterk. Deze studie rapporteerde voor het eerst de invloed van verschillen in infectietemperatuur op het fenotype en de functie van geproduceerde CAR-T-cellen.

Onze resultaten laten zien dat infectie bij four graden de hoogste CAR-positieve snelheid van T-cellen produceert, infectie bij 37 graden produceert de snelste proliferatie in CAR-T-cellen, en infectie bij 32 graden produceert CAR-T-cellen met het grootste aandeel naïeve cellen en de laagste expressie van immuuncheckpoints. Daarom wordt infectie bij 32 graden aanbevolen om CAR-T-cellen te bereiden. CAR-T-cellen afkomstig van infectie bij 32 graden lijken een balans te hebben tussen functie en fenotype. Belangrijk is dat ze een verhoogd oncolytisch vermogen hebben. Dit onderzoek zal de generatie van CAR-T-cellen helpen optimaliseren en de kwaliteit van CAR-T-celproducten verbeteren.

 

Ontwikkeling van een  antigeen- antilichaam-co-displaysysteem voor het detecteren van interactie van G-eiwit-gekoppelde  receptoren  en variabele fragmenten met één keten

G-proteïne-gekoppelde receptoren (GPCR’s), vooral chemokinereceptoren, zijn ideale doelwitten voor geneesmiddelen met monoklonale antilichamen. Gezien de speciale multi-pass transmembraanstructuur van GPCR, is het vaak een moeizame taak om antilichaaminformatie te verkrijgen over off-targets en epitopen op antigenen. Om het proces te versnellen, moet een snelle en eenvoudige methode worden ontwikkeld. Het op split-ubiquitine gebaseerde gist twee hybride systeem (YTH) werd gebruikt als een blauw script voor een nieuwe methode. Door te fuseren met transmembraanpeptiden, werden scFv-antilichamen ontworpen om te worden verankerd op het cytomembraan, waar ook de GPCR werd getoond. Het gekoppelde split-ubiquitinesysteem transformeerde het scFv-GPCR- interactiesignaal in de expressie van reportergenen.

Door de topologische structuur van scFv-fusie-eiwit en sleutelelementen, waaronder signaalpeptiden, transmembraanpeptiden en flexibele linkers, te optimaliseren , werd een systeem met de naam Antigen-Antibody Co-Show (AACD) opgezet, dat snel de interacties tussen antilichamen en hun doel-GPCR’s detecteerde , CXCR4 en CXCR5, terwijl ook de off-target antilichamen en antilichaam-geassocieerde epitopen worden bepaald. Het AACD-systeem kan snel de associatie tussen GPCR’s en hun kandidaat-antilichamen bepalen en de onderzoeksperiode voor off-target detectie en epitoopidentificatie verkorten. Dit systeem moet het proces van de ontwikkeling van GPCR-antilichamen verbeteren en een nieuwe strategie bieden voor het screenen van GPCR-antilichamen.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse)
4-PAA682Mu01	Cloud-Clone	EUR 283.20 EUR 2805.60 EUR 703.20 EUR 352.80 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12)

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), PE
4-PAA682Mu01-PE	Cloud-Clone	EUR 339.60 EUR 2942.40 EUR 843.60 EUR 423.60 EUR 226.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with PE.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC
4-PAA682Mu01-APC	Cloud-Clone	EUR 394.80 EUR 3649.20 EUR 1024.80 EUR 499.20 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Cy3
4-PAA682Mu01-Cy3	Cloud-Clone	EUR 476.40 EUR 4815.60 EUR 1316.40 EUR 615.60 EUR 289.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), HRP
4-PAA682Mu01-HRP	Cloud-Clone	EUR 362.40 EUR 3182.40 EUR 907.20 EUR 452.40 EUR 240.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat)
4-PAA682Ra01	Cloud-Clone	EUR 291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12)

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), FITC
4-PAA682Mu01-FITC	Cloud-Clone	EUR 339.60 EUR 2942.40 EUR 843.60 EUR 423.60 EUR 226.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Biotinylated
4-PAA682Mu01-Biotin	Cloud-Clone	EUR 358.80 EUR 2745.60 EUR 820.80 EUR 435.60 EUR 256.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Biotin.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), PE
4-PAA682Ra01-PE	Cloud-Clone	EUR 350.40 EUR 3098.40 EUR 882.00 EUR 439.20 EUR 232.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with PE.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), APC
4-PAA682Ra01-APC	Cloud-Clone	EUR 408.00 EUR 3843.60 EUR 1072.80 EUR 518.40 EUR 260.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), Cy3
4-PAA682Ra01-Cy3	Cloud-Clone	EUR 493.20 EUR 5074.80 EUR 1381.20 EUR 642.00 EUR 297.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), HRP
4-PAA682Ra01-HRP	Cloud-Clone	EUR 373.20 EUR 3350.40 EUR 949.20 EUR 469.20 EUR 246.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), FITC
4-PAA682Ra01-FITC	Cloud-Clone	EUR 350.40 EUR 3098.40 EUR 882.00 EUR 439.20 EUR 232.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC-Cy7
4-PAA682Mu01-APC-Cy7	Cloud-Clone	EUR 645.60 EUR 7154.40 EUR 1905.60 EUR 855.60 EUR 364.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC-Cy7.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), Biotinylated
4-PAA682Ra01-Biotin	Cloud-Clone	EUR 368.40 EUR 2888.40 EUR 856.80 EUR 450.00 EUR 260.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with Biotin.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), APC-Cy7
4-PAA682Ra01-APC-Cy7	Cloud-Clone	EUR 672.00 EUR 7543.20 EUR 2002.80 EUR 894.00 EUR 378.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with APC-Cy7.

Rabbit Anti Caspase-12 (Aa100-116) Polyclonal Antibody
CPBT-66303RC	Creative Diagnostics	0.1 mg	EUR 696

Caspase 3 rabbit polyclonal antibody
E12-411	EnoGene	100ug/100ul	EUR 255
Description: Available in various conjugation types.

Caspase 8 rabbit polyclonal antibody
E12-415	EnoGene	100ug/100ul	EUR 255
Description: Available in various conjugation types.

Rabbit Anti Human Caspase-2 Polyclonal Antibody
CPBT-66277RH	Creative Diagnostics	50 µg	EUR 1182

Rabbit Anti Human Caspase-3 Polyclonal Antibody
CPBT-66278RH	Creative Diagnostics	10 µl*	EUR 514.8

Rabbit Anti Human Caspase-3 Polyclonal Antibody
CPBT-66279RH	Creative Diagnostics	0.1 ml	EUR 920.4

Rabbit Anti Human Caspase-5 Polyclonal Antibody
CPBT-66285RH	Creative Diagnostics	0.1 mg	EUR 696

Caspase 12 (CASP12) Antibody
20-abx318255	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (Casp12) Antibody
20-abx318989	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (CASP12) Antibody
20-abx210324	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Caspase 12 (CASP12) Antibody
20-abx213378	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Caspase 12 (CASP12) Antibody
abx216233-100ug	Abbexa	100 ug	EUR 526.8

Caspase 12 (CASP12) Antibody
20-abx324638	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Caspase 12 (CASP12) Antibody
20-abx111421	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Caspase 12 (CASP12) Antibody
abx026563-400ul	Abbexa	400 ul	EUR 627.6

Caspase 12 (CASP12) Antibody
abx026563-80l	Abbexa	80 µl	EUR 343.2

Caspase 12 (CASP12) Antibody
20-abx100899	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Caspase 12 (CASP12) Antibody
20-abx129818	Abbexa	EUR 493.20 EUR 159.60 EUR 1362.00 EUR 661.20 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Caspase 12 Polyclonal Antibody
ABP50853-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody
ABP50853-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody
ABP50853-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody
ABP50853-100uL	Abbkine	100 μL	EUR 239
Description: Rabbit Anti-Caspase12 Polyclonal Antibody

Caspase 12 Polyclonal Antibody
ABP50853-200uL	Abbkine	200 μL	EUR 379
Description: Rabbit Anti-Caspase12 Polyclonal Antibody

Caspase 12 Polyclonal Antibody
ABP50853-30uL	Abbkine	30 μL	EUR 109
Description: Rabbit Anti-Caspase12 Polyclonal Antibody

Polyclonal Caspase-12 Antibody
APR00058G	Leading Biology	0.1mg	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody
APR06275G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody
APR06276G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Rabbit Anti Caspase-14 (C-Terminal) Polyclonal Antibody
CPBT-66307RC	Creative Diagnostics	0.1 mg	EUR 852

Rabbit Anti Caspase-4 (N-Terminal) Polyclonal Antibody
CPBT-66281RC	Creative Diagnostics	50 µg	EUR 795.6

Rabbit Anti Caspase-4 (N-Terminal) Polyclonal Antibody
CPBT-66282RC	Creative Diagnostics	0.1 mg	EUR 852

Rabbit Anti Caspase-7 (N-Terminal) Polyclonal Antibody
CPBT-66291RC	Creative Diagnostics	0.1 mg	EUR 795.6

Caspase 12 (CASP12) Antibody (HRP)
20-abx316303	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (Casp12) Antibody (HRP)
20-abx318990	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (CASP12) Antibody (FITC)
20-abx316304	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (Casp12) Antibody (FITC)
20-abx318991	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (CASP12) Antibody (Biotin)
20-abx316305	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (Casp12) Antibody (Biotin)
20-abx318992	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Polyclonal Caspase-12 Antibody (Large)
APR06327G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Large). This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody (Small)
APR06328G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Small). This antibody is tested and proven to work in the following applications:

Rabbit Anti Human Caspase-1 (C-Terminal) Polyclonal Antibody
CPBT-66276RH	Creative Diagnostics	0.1 mg	EUR 1070.4

Caspase 10 (CASP10) polyclonal antibody
ABP-PAB-10300	Allele Biotech	100 ug	Ask for price

Caspase 10 (CASP10) Polyclonal Antibody
CAU26437-100ul	Biomatik Corporation	100ul	EUR 222.7

Caspase 10 (CASP10) Polyclonal Antibody
CAU26437-200ul	Biomatik Corporation	200ul	EUR 278.9

Caspase 14 (CASP14) Polyclonal Antibody
CAU27862-100ul	Biomatik Corporation	100ul	EUR 229.4

Caspase 14 (CASP14) Polyclonal Antibody
CAU27862-200ul	Biomatik Corporation	200ul	EUR 287.3

Caspase 14 (CASP14) Polyclonal Antibody
CAU27863-100ul	Biomatik Corporation	100ul	EUR 217.9

Caspase 14 (CASP14) Polyclonal Antibody
CAU27863-200ul	Biomatik Corporation	200ul	EUR 272.2

Caspase 14 (CASP14) Polyclonal Antibody
CAU27864-100ul	Biomatik Corporation	100ul	EUR 217.9

Caspase 14 (CASP14) Polyclonal Antibody
CAU27864-200ul	Biomatik Corporation	200ul	EUR 272.2

Caspase 14 (CASP14) Polyclonal Antibody
CAU27865-100ul	Biomatik Corporation	100ul	EUR 212.2

Caspase 14 (CASP14) Polyclonal Antibody
CAU27865-200ul	Biomatik Corporation	200ul	EUR 265.4

Caspase 2 (CASP2) Polyclonal Antibody
CAU29922-100ul	Biomatik Corporation	100ul	EUR 211.2

Caspase 2 (CASP2) Polyclonal Antibody
CAU29922-200ul	Biomatik Corporation	200ul	EUR 263.8

Caspase 6 (CASP6) Polyclonal Antibody
CAU24387-100ul	Biomatik Corporation	100ul	EUR 235.2

Caspase 6 (CASP6) Polyclonal Antibody
CAU24387-200ul	Biomatik Corporation	200ul	EUR 294

Caspase 6 (CASP6) Polyclonal Antibody
CAU24388-100ul	Biomatik Corporation	100ul	EUR 282.2

Caspase 6 (CASP6) Polyclonal Antibody
CAU24388-200ul	Biomatik Corporation	200ul	EUR 352.8

Caspase 6 (CASP6) Polyclonal Antibody
CAU24389-100ul	Biomatik Corporation	100ul	EUR 282.2

Caspase 6 (CASP6) Polyclonal Antibody
CAU24389-200ul	Biomatik Corporation	200ul	EUR 352.8

Caspase 4 (CASP4) Polyclonal Antibody
CAU25409-100ul	Biomatik Corporation	100ul	EUR 229.4

Caspase 4 (CASP4) Polyclonal Antibody
CAU25409-200ul	Biomatik Corporation	200ul	EUR 287.3

Caspase 4 (CASP4) Polyclonal Antibody
CAU25410-100ul	Biomatik Corporation	100ul	EUR 229.4

Caspase 4 (CASP4) Polyclonal Antibody
CAU25410-200ul	Biomatik Corporation	200ul	EUR 287.3

Caspase 4 (CASP4) Polyclonal Antibody
CAU25411-100ul	Biomatik Corporation	100ul	EUR 222.7

Caspase 4 (CASP4) Polyclonal Antibody
CAU25411-200ul	Biomatik Corporation	200ul	EUR 278.9

Caspase 4 (CASP4) Polyclonal Antibody
CAU25412-100ul	Biomatik Corporation	100ul	EUR 222.7

Caspase 4 (CASP4) Polyclonal Antibody
CAU25412-200ul	Biomatik Corporation	200ul	EUR 278.9

Caspase 4 (CASP4) Polyclonal Antibody
CAU25413-100ul	Biomatik Corporation	100ul	EUR 268.8

Caspase 4 (CASP4) Polyclonal Antibody
CAU25413-200ul	Biomatik Corporation	200ul	EUR 336

Caspase 4 (CASP4) Polyclonal Antibody
CAU25414-100ul	Biomatik Corporation	100ul	EUR 268.8

Caspase 4 (CASP4) Polyclonal Antibody
CAU25414-200ul	Biomatik Corporation	200ul	EUR 336

Caspase 1 (CASP1) Polyclonal Antibody
CAU25660-100ul	Biomatik Corporation	100ul	EUR 242.9

Caspase 1 (CASP1) Polyclonal Antibody
CAU25660-200ul	Biomatik Corporation	200ul	EUR 304.1

Caspase 1 (CASP1) Polyclonal Antibody
CAU25661-100ul	Biomatik Corporation	100ul	EUR 268.8

Caspase 1 (CASP1) Polyclonal Antibody
CAU25661-200ul	Biomatik Corporation	200ul	EUR 336

Caspase 1 (CASP1) Polyclonal Antibody
CAU25662-100ul	Biomatik Corporation	100ul	EUR 229.4

Caspase 1 (CASP1) Polyclonal Antibody
CAU25662-200ul	Biomatik Corporation	200ul	EUR 287.3

Caspase 1 (CASP1) Polyclonal Antibody
CAU25663-100ul	Biomatik Corporation	100ul	EUR 222.7

Caspase 1 (CASP1) Polyclonal Antibody
CAU25663-200ul	Biomatik Corporation	200ul	EUR 278.9

Caspase 1 (CASP1) Polyclonal Antibody
CAU25664-100ul	Biomatik Corporation	100ul	EUR 222.7

Caspase 1 (CASP1) Polyclonal Antibody
CAU25664-200ul	Biomatik Corporation	200ul	EUR 278.9

Caspase 8 (CASP8) Polyclonal Antibody
CAU26950-100ul	Biomatik Corporation	100ul	EUR 204.5

Caspase 8 (CASP8) Polyclonal Antibody
CAU26950-200ul	Biomatik Corporation	200ul	EUR 255.4

Caspase 8 (CASP8) Polyclonal Antibody
CAU26951-100ul	Biomatik Corporation	100ul	EUR 217.9

Caspase 8 (CASP8) Polyclonal Antibody
CAU26951-200ul	Biomatik Corporation	200ul	EUR 272.2

Caspase 8 (CASP8) Polyclonal Antibody
CAU26952-100ul	Biomatik Corporation	100ul	EUR 193.9

Caspase 8 (CASP8) Polyclonal Antibody
CAU26952-200ul	Biomatik Corporation	200ul	EUR 241.9

Caspase 8 (CASP8) Polyclonal Antibody
CAU26953-100ul	Biomatik Corporation	100ul	EUR 188.2

Caspase 8 (CASP8) Polyclonal Antibody
CAU26953-200ul	Biomatik Corporation	200ul	EUR 235.2

Caspase 8 (CASP8) Polyclonal Antibody
CAU26954-100ul	Biomatik Corporation	100ul	EUR 188.2

Caspase 8 (CASP8) Polyclonal Antibody
CAU26954-200ul	Biomatik Corporation	200ul	EUR 235.2

Caspase 8 (CASP8) Polyclonal Antibody
CAU26955-100ul	Biomatik Corporation	100ul	EUR 188.2

Caspase 8 (CASP8) Polyclonal Antibody
CAU26955-200ul	Biomatik Corporation	200ul	EUR 235.2

Caspase 8 (CASP8) Polyclonal Antibody
CAU26956-100ul	Biomatik Corporation	100ul	EUR 254.4

Caspase 8 (CASP8) Polyclonal Antibody
CAU26956-200ul	Biomatik Corporation	200ul	EUR 317.5

Caspase 7 (CASP7) Polyclonal Antibody
CAU27875-100ul	Biomatik Corporation	100ul	EUR 204.5

Caspase 7 (CASP7) Polyclonal Antibody
CAU27875-200ul	Biomatik Corporation	200ul	EUR 255.4

Caspase 7 (CASP7) Polyclonal Antibody
CAU27876-100ul	Biomatik Corporation	100ul	EUR 217.9

Caspase 7 (CASP7) Polyclonal Antibody
CAU27876-200ul	Biomatik Corporation	200ul	EUR 272.2

Caspase 7 (CASP7) Polyclonal Antibody
CAU27877-100ul	Biomatik Corporation	100ul	EUR 193.9

Caspase 7 (CASP7) Polyclonal Antibody
CAU27877-200ul	Biomatik Corporation	200ul	EUR 241.9

Caspase 7 (CASP7) Polyclonal Antibody
CAU27878-100ul	Biomatik Corporation	100ul	EUR 188.2

Caspase 7 (CASP7) Polyclonal Antibody
CAU27878-200ul	Biomatik Corporation	200ul	EUR 235.2

Caspase 7 (CASP7) Polyclonal Antibody
CAU27879-100ul	Biomatik Corporation	100ul	EUR 188.2

Caspase 7 (CASP7) Polyclonal Antibody
CAU27879-200ul	Biomatik Corporation	200ul	EUR 235.2

Caspase 5 (CASP5) Polyclonal Antibody
CAU27193-100ul	Biomatik Corporation	100ul	EUR 212.2

Caspase 5 (CASP5) Polyclonal Antibody
CAU27193-200ul	Biomatik Corporation	200ul	EUR 265.4

Caspase 9 (CASP9) Polyclonal Antibody
CAU27497-100ul	Biomatik Corporation	100ul	EUR 229.4

Caspase 9 (CASP9) Polyclonal Antibody
CAU27497-200ul	Biomatik Corporation	200ul	EUR 287.3

Caspase 9 (CASP9) Polyclonal Antibody
CAU27498-100ul	Biomatik Corporation	100ul	EUR 217.9

Caspase 9 (CASP9) Polyclonal Antibody
CAU27498-200ul	Biomatik Corporation	200ul	EUR 272.2

Caspase 9 (CASP9) Polyclonal Antibody
CAU27499-100ul	Biomatik Corporation	100ul	EUR 211.2

Caspase 9 (CASP9) Polyclonal Antibody
CAU27499-200ul	Biomatik Corporation	200ul	EUR 263.8

Caspase 9 (CASP9) Polyclonal Antibody
CAU27500-100ul	Biomatik Corporation	100ul	EUR 212.2

Caspase 9 (CASP9) Polyclonal Antibody
CAU27500-200ul	Biomatik Corporation	200ul	EUR 265.4

Caspase 9 (CASP9) Polyclonal Antibody
CAU27501-100ul	Biomatik Corporation	100ul	EUR 212.2

Caspase 9 (CASP9) Polyclonal Antibody
CAU27501-200ul	Biomatik Corporation	200ul	EUR 265.4

Caspase 3 (CASP3) Polyclonal Antibody
CAU27502-100ul	Biomatik Corporation	100ul	EUR 229.4

Caspase 3 (CASP3) Polyclonal Antibody
CAU27502-200ul	Biomatik Corporation	200ul	EUR 287.3

Caspase 3 (CASP3) Polyclonal Antibody
CAU27503-100ul	Biomatik Corporation	100ul	EUR 229.4

Caspase 3 (CASP3) Polyclonal Antibody
CAU27503-200ul	Biomatik Corporation	200ul	EUR 287.3

Caspase 3 (CASP3) Polyclonal Antibody
CAU27504-100ul	Biomatik Corporation	100ul	EUR 217.9

Caspase 3 (CASP3) Polyclonal Antibody
CAU27504-200ul	Biomatik Corporation	200ul	EUR 272.2

Caspase 3 (CASP3) Polyclonal Antibody
CAU27505-100ul	Biomatik Corporation	100ul	EUR 211.2

Caspase 3 (CASP3) Polyclonal Antibody
CAU27505-200ul	Biomatik Corporation	200ul	EUR 263.8

Caspase 3 (CASP3) Polyclonal Antibody
CAU27506-100ul	Biomatik Corporation	100ul	EUR 212.2

Caspase 3 (CASP3) Polyclonal Antibody
CAU27506-200ul	Biomatik Corporation	200ul	EUR 265.4

Caspase 2 (CASP2) Polyclonal Antibody
CAU28261-100ul	Biomatik Corporation	100ul	EUR 217.9

Caspase 2 (CASP2) Polyclonal Antibody
CAU28261-200ul	Biomatik Corporation	200ul	EUR 272.2

Caspase 2 (CASP2) Polyclonal Antibody
CAU28262-100ul	Biomatik Corporation	100ul	EUR 212.2

Caspase 2 (CASP2) Polyclonal Antibody
CAU28262-200ul	Biomatik Corporation	200ul	EUR 265.4

Caspase 14 (CASP14) Polyclonal Antibody (Rat)
4-PAA457Ra01	Cloud-Clone	EUR 291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 14 (CASP14)

Caspase 14 (CASP14) Polyclonal Antibody (Human)
4-PAA457Hu01	Cloud-Clone	EUR 278.40 EUR 2742.00 EUR 688.80 EUR 346.80 EUR 249.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 14 (CASP14)

Caspase 14 (CASP14) Polyclonal Antibody (Mouse)
4-PAA457Mu01	Cloud-Clone	EUR 283.20 EUR 2805.60 EUR 703.20 EUR 352.80 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 14 (CASP14)

Caspase 14 (CASP14) Polyclonal Antibody (Mouse)
4-PAA457Mu02	Cloud-Clone	EUR 283.20 EUR 2805.60 EUR 703.20 EUR 352.80 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 14 (CASP14)

Caspase 11 (CASP11) Polyclonal Antibody (Human)
4-PAA094Hu01	Cloud-Clone	EUR 278.40 EUR 2726.40 EUR 685.20 EUR 345.60 EUR 248.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 11 (CASP11)

Caspase 11 (CASP11) Polyclonal Antibody (Mouse)
4-PAA094Mu01	Cloud-Clone	EUR 283.20 EUR 2805.60 EUR 703.20 EUR 352.80 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 11 (CASP11)

Caspase 3 (CASP3) Polyclonal Antibody (Rat)
4-PAA626Ra02	Cloud-Clone	EUR 291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 3 (CASP3)

Caspase 9 (CASP9) Polyclonal Antibody (Rat)
4-PAA627Ra01	Cloud-Clone	EUR 291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 9 (CASP9)

Caspase 8 (CASP8) Polyclonal Antibody (Rat)
4-PAA853Ra01	Cloud-Clone	EUR 272.40 EUR 2647.20 EUR 667.20 EUR 338.40 EUR 246.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 8 (CASP8)

Caspase 7 (CASP7) Polyclonal Antibody (Rat)
4-PAA449Ra01	Cloud-Clone	EUR 272.40 EUR 2647.20 EUR 667.20 EUR 338.40 EUR 246.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 7 (CASP7)

Caspase 14 (CASP14) Polyclonal Antibody (Rat), PE
4-PAA457Ra01-PE	Cloud-Clone	EUR 350.40 EUR 3098.40 EUR 882.00 EUR 439.20 EUR 232.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 14 (CASP14). This antibody is labeled with PE.

Caspase 14 (CASP14) Polyclonal Antibody (Rat), APC
4-PAA457Ra01-APC	Cloud-Clone	EUR 408.00 EUR 3843.60 EUR 1072.80 EUR 518.40 EUR 260.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 14 (CASP14). This antibody is labeled with APC.

Caspase 14 (CASP14) Polyclonal Antibody (Rat), Cy3
4-PAA457Ra01-Cy3	Cloud-Clone	EUR 493.20 EUR 5074.80 EUR 1381.20 EUR 642.00 EUR 297.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 14 (CASP14). This antibody is labeled with Cy3.

Caspase 14 (CASP14) Polyclonal Antibody (Rat), HRP
4-PAA457Ra01-HRP	Cloud-Clone	EUR 373.20 EUR 3350.40 EUR 949.20 EUR 469.20 EUR 246.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 14 (CASP14). This antibody is labeled with HRP.

Caspase 5 (CASP5) Polyclonal Antibody (Human)
4-PAA770Hu01	Cloud-Clone	EUR 278.40 EUR 2742.00 EUR 688.80 EUR 346.80 EUR 249.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 5 (CASP5)

Caspase 3 (CASP3) Polyclonal Antibody (Human)
4-PAA626Hu01	Cloud-Clone	EUR 278.40 EUR 2742.00 EUR 688.80 EUR 346.80 EUR 249.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 3 (CASP3)

Caspase 3 (CASP3) Polyclonal Antibody (Human)
4-PAA626Hu02	Cloud-Clone	EUR 278.40 EUR 2726.40 EUR 685.20 EUR 345.60 EUR 248.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 3 (CASP3)

Caspase 3 (CASP3) Polyclonal Antibody (Mouse)
4-PAA626Mu01	Cloud-Clone	EUR 283.20 EUR 2805.60 EUR 703.20 EUR 352.80 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 3 (CASP3)

Caspase 9 (CASP9) Polyclonal Antibody (Human)
4-PAA627Hu01	Cloud-Clone	EUR 278.40 EUR 2742.00 EUR 688.80 EUR 346.80 EUR 249.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 9 (CASP9)

Caspase 9 (CASP9) Polyclonal Antibody (Human)
4-PAA627Hu02	Cloud-Clone	EUR 278.40 EUR 2742.00 EUR 688.80 EUR 346.80 EUR 249.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 9 (CASP9)

Caspase 8 (CASP8) Polyclonal Antibody (Human)
4-PAA853Hu01	Cloud-Clone	EUR 260.40 EUR 2457.60 EUR 624.00 EUR 321.60 EUR 241.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 8 (CASP8)

Caspase 8 (CASP8) Polyclonal Antibody (Human)
4-PAA853Hu03	Cloud-Clone	EUR 260.40 EUR 2457.60 EUR 624.00 EUR 321.60 EUR 241.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 8 (CASP8)

Caspase 8 (CASP8) Polyclonal Antibody (Mouse)
4-PAA853Mu01	Cloud-Clone	EUR 265.20 EUR 2520.00 EUR 638.40 EUR 326.40 EUR 242.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 8 (CASP8)

Caspase 7 (CASP7) Polyclonal Antibody (Human)
4-PAA449Hu01	Cloud-Clone	EUR 260.40 EUR 2457.60 EUR 624.00 EUR 321.60 EUR 241.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 7 (CASP7)

Caspase 7 (CASP7) Polyclonal Antibody (Human)
4-PAA449Hu02	Cloud-Clone	EUR 260.40 EUR 2457.60 EUR 624.00 EUR 321.60 EUR 241.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 7 (CASP7)

Caspase 7 (CASP7) Polyclonal Antibody (Mouse)
4-PAA449Mu01	Cloud-Clone	EUR 265.20 EUR 2520.00 EUR 638.40 EUR 326.40 EUR 242.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 7 (CASP7)

Caspase 7 (CASP7) Polyclonal Antibody (Mouse)
4-PAA449Mu02	Cloud-Clone	EUR 283.20 EUR 2805.60 EUR 703.20 EUR 352.80 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 7 (CASP7)

Caspase 2 (CASP2) Polyclonal Antibody (Mouse)
4-PAA244Hu01	Cloud-Clone	EUR 278.40 EUR 2742.00 EUR 688.80 EUR 346.80 EUR 249.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 2 (CASP2)

Caspase 2 (CASP2) Polyclonal Antibody (Human)
4-PAA244Hu02	Cloud-Clone	EUR 278.40 EUR 2726.40 EUR 685.20 EUR 345.60 EUR 248.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 2 (CASP2)

Caspase 2 (CASP2) Polyclonal Antibody (Mouse)
4-PAA244Mu01	Cloud-Clone	EUR 283.20 EUR 2805.60 EUR 703.20 EUR 352.80 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 2 (CASP2)

Caspase 1 (CASP1) Polyclonal Antibody (Human)
4-PAB592Hu01	Cloud-Clone	EUR 286.80 EUR 2869.20 EUR 717.60 EUR 358.80 EUR 253.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 1 (CASP1)

Caspase 1 (CASP1) Polyclonal Antibody (Human)
4-PAB592Hu02	Cloud-Clone	EUR 286.80 EUR 2869.20 EUR 717.60 EUR 358.80 EUR 253.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 1 (CASP1)

Caspase 1 (CASP1) Polyclonal Antibody (Mouse)
4-PAB592Mu01	Cloud-Clone	EUR 291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 1 (CASP1)

Caspase 4 (CASP4) Polyclonal Antibody (Human)
4-PAB735Hu01	Cloud-Clone	EUR 286.80 EUR 2869.20 EUR 717.60 EUR 358.80 EUR 253.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 4 (CASP4)

Caspase 4 (CASP4) Polyclonal Antibody (Human)
4-PAB735Hu02	Cloud-Clone	EUR 286.80 EUR 2869.20 EUR 717.60 EUR 358.80 EUR 253.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 4 (CASP4)

Caspase 4 (CASP4) Polyclonal Antibody (Mouse)
4-PAB735Mu01	Cloud-Clone	EUR 291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 4 (CASP4)

Caspase 4 (CASP4) Polyclonal Antibody (Mouse)
4-PAB735Mu02	Cloud-Clone	EUR 291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 4 (CASP4)

Caspase 6 (CASP6) Polyclonal Antibody (Human)
4-PAC340Hu01	Cloud-Clone	EUR 296.40 EUR 3012.00 EUR 750.00 EUR 372.00 EUR 256.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 6 (CASP6)

Caspase 14 (CASP14) Polyclonal Antibody (Human), PE
4-PAA457Hu01-PE	Cloud-Clone	EUR 334.80 EUR 2874.00 EUR 825.60 EUR 416.40 EUR 225.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 14 (CASP14). This antibody is labeled with PE.

Caspase 14 (CASP14) Polyclonal Antibody (Mouse), PE
4-PAA457Mu01-PE	Cloud-Clone	EUR 339.60 EUR 2942.40 EUR 843.60 EUR 423.60 EUR 226.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 14 (CASP14). This antibody is labeled with PE.

Caspase 14 (CASP14) Polyclonal Antibody (Mouse), PE
4-PAA457Mu02-PE	Cloud-Clone	EUR 339.60 EUR 2942.40 EUR 843.60 EUR 423.60 EUR 226.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 14 (CASP14). This antibody is labeled with PE.

Caspase 14 (CASP14) Polyclonal Antibody (Rat), FITC
4-PAA457Ra01-FITC	Cloud-Clone	EUR 350.40 EUR 3098.40 EUR 882.00 EUR 439.20 EUR 232.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Caspase 14 (CASP14). This antibody is labeled with FITC.

Caspase 11 (CASP11) Polyclonal Antibody (Human), PE
4-PAA094Hu01-PE	Cloud-Clone	EUR 333.60 EUR 2856.00 EUR 822.00 EUR 415.20 EUR 224.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Caspase 11 (CASP11). This antibody is labeled with PE.

Caspase 11 (CASP11) Polyclonal Antibody (Mouse), PE
4-PAA094Mu01-PE	Cloud-Clone	EUR 339.60 EUR 2942.40 EUR 843.60 EUR 423.60 EUR 226.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 11 (CASP11). This antibody is labeled with PE.

Caspase 8 (CASP8) Polyclonal Antibody (Bovine)
4-PAA853Bo01	Cloud-Clone	EUR 310.80 EUR 3232.80 EUR 800.40 EUR 391.20 EUR 261.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Bovine Caspase 8 (CASP8)

Caspase 4 (CASP4) Polyclonal Antibody (Bovine)
4-PAB735Bo02	Cloud-Clone	EUR 321.60 EUR 3408.00 EUR 840.00 EUR 408.00 EUR 267.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Bovine Caspase 4 (CASP4)

Caspase 6 (CASP6) Polyclonal Antibody (Bovine)
4-PAC340Bo01	Cloud-Clone	EUR 331.20 EUR 3566.40 EUR 876.00 EUR 422.40 EUR 271.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Bovine Caspase 6 (CASP6)

Caspase 6 (CASP6) Polyclonal Antibody (Bovine)
4-PAC340Bo02	Cloud-Clone	EUR 331.20 EUR 3566.40 EUR 876.00 EUR 422.40 EUR 271.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Bovine Caspase 6 (CASP6)

Ontwikkeling van een  antigeen- antilichaam-co-displaysysteem voor het detecteren van interactie van G-eiwit-gekoppelde  receptoren  en variabele fragmenten met één keten

G-proteïne-gekoppelde receptoren (GPCR’s), vooral chemokinereceptoren, zijn ideale doelwitten voor geneesmiddelen met monoklonale antilichamen. Gezien de speciale multi-pass transmembraanstructuur van GPCR, is het vaak een moeizame taak om antilichaaminformatie te verkrijgen over off-targets en epitopen op antigenen. Om het proces te versnellen, moet een snelle en eenvoudige methode worden ontwikkeld . Het op split-ubiquitine gebaseerde gist twee hybride systeem (YTH) werd gebruikt als een blauw script voor een nieuwe methode. Door te fuseren met transmembraanpeptiden, werden scFv-antilichamen ontworpen om te worden verankerd op het cytomembraan, waar ook de GPCR werd getoond. Het gekoppelde split-ubiquitinesysteem transformeerde het scFv-GPCR-interactiesignaal in de expressie van reportergenen.

Door de topologische structuur van scFv- fusie-eiwit en sleutelelementen, waaronder signaalpeptiden, transmembraanpeptiden en flexibele linkers, te optimaliseren , werd een systeem met de naam Antigen-Antibody Co-Show (AACD) opgezet, dat snel de interacties tussen antilichamen en hun doel-GPCR’s detecteerde , CXCR4 en CXCR5, terwijl ook de off-target antilichamen en antilichaam-geassocieerde epitopen worden bepaald. Het AACD-systeem kan snel de associatie tussen GPCR’s en hun kandidaat-antilichamen bepalen en de onderzoeksperiode voor off-target detectie en epitoopidentificatie verkorten. Dit systeem moet het proces van de ontwikkeling van GPCR-antilichamen verbeteren en een nieuwe strategie bieden voor het screenen van GPCR-antilichamen.

Chimere  Antigeen  Receptor -gemodificeerde T-cellen en T-Cell Partaking Bispecifieke antilichamen: Verschillende Hulpmiddelen voor hetzelfde werk

Doel van de beoordeling:  Zowel chimere antigeenreceptor (CAR) T-cellen als T-cel-aangrijpende antilichamen (BiAb) zijn goedgekeurd voor de behandeling van hematologische maligniteiten. Ondanks dat ze zich op hetzelfde antigeen richten, vertegenwoordigen ze echter zeer verschillende klassen van therapieën, elk met zijn duidelijke voor- en nadelen. In deze evaluation vergelijken we BiAb- en CAR T-cellen met betrekking tot hun werkingsmechanisme, productie en klinische toepassing. Daarnaast presenteren we nieuwe strategieën om de beperkingen van beide benaderingen te overwinnen en het beste van beide werelden te combineren.

Recente bevindingen:  Inmiddels zijn er meerdere benaderingen die de voordelen van BiAb en CAR T-cellen combineren. Een belangrijk onderzoeksgebied is de toepassing van beide formaten voor solide tumorentiteiten. Dit omvat het verbeteren van de infiltratie van T-cellen in de tumor, het tegengaan van immunosuppressie in de micro-omgeving van de tumor, het richten op antigeenheterogeniteit en het beperken van off-tumor on-target effecten . BiAb heeft het grote voordeel dat het een kant-en-klaar product is en beter controleerbaar is vanwege hun halfwaardetijd. Er is ook gemeld dat ze minder frequente en minder ernstige bijwerkingen veroorzaken. CAR T-cellen vertonen op hun beurt superieure responspercentages, hebben het potentieel voor persistentie op de lange termijn en kunnen bovendien genetisch worden gemodificeerd om bepaalde problemen te overwinnen. van hun beperkingen, bijvoorbeeld om ze beter beheersbaar te maken.

Chimeer  antigen  receptor  pure killer (CAR-NK) cel ontwerp en engineering voor kankertherapie

Vanwege hun efficiënte herkenning en lysis van kwaadaardige cellen , worden pure killer (NK)-cellen beschouwd als gespecialiseerde immuuncellen die genetisch kunnen worden gemodificeerd om capabele effectorcellen te verkrijgen voor adoptieve cellulaire behandeling van kankerpatiënten. Biologische en technische hindernissen met betrekking tot genafgifte in NK-cellen hebben de vooruitgang echter dramatisch beperkt. Recente technologische ontwikkelingen, waaronder verbeterde celexpansietechnieken, chimere antigeenreceptoren (CAR) , CRISPR/Cas9-genediting en verbeterde virale transductie en elektroporatie, hebben een uitgebreide generatie en karakterisering van genetisch gemodificeerde NK-cellen mogelijk gemaakt. Deze veelbelovende ontwikkelingen helpen wetenschappers en artsen om betere toepassingen van NK-cellen in de klinische praktijk te ontwerpentherapie. Met identify het omleiden van NK-cellen met behulp van CAR’s houdt een belangrijke belofte in voor immunotherapie van kanker.

Various preklinische en een beperkt aantal klinische onderzoeken met CAR-NK- cellen laten veelbelovende resultaten zien: efficiënte eliminatie van doelcellen zonder bijwerkingen, zoals cytokine-release-syndroom en neurotoxiciteit die worden gezien bij CAR-T-therapieën. In deze evaluation concentreren we ons op de particulars van CAR-NK-technologie, inclusief het ontwerp van efficiënte en veilige CAR-constructies en bijbehorende NK-cel-engineeringtechnieken: de voertuigen om het CAR-bevattende transgen af te leveren., detectiemethoden voor CAR’s, evenals NK-celbronnen en NK-celexpansie. We vatten de huidige literatuur over CAR-NK-cellen samen en omvatten waardevolle reduce die zijn geleerd uit het CAR-T-celveld. Deze beoordeling biedt ook een kijk op hoe deze benaderingen de huidige klinische producten en protocollen voor de behandeling van kanker kunnen transformeren.

 

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), HRP
4-PAC213Hu01-HRP	Cloud-Clone	EUR 379.20 EUR 3426.00 EUR 968.40 EUR 477.60 EUR 247.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC
4-PAC213Mu01-APC	Cloud-Clone	EUR 421.20 EUR 4038.00 EUR 1122.00 EUR 538.80 EUR 266.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Cy3
4-PAC213Mu01-Cy3	Cloud-Clone	EUR 512.40 EUR 5334.00 EUR 1446.00 EUR 668.40 EUR 304.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), HRP
4-PAC213Mu01-HRP	Cloud-Clone	EUR 385.20 EUR 3519.60 EUR 992.40 EUR 486.00 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), FITC
4-PAC213Hu01-FITC	Cloud-Clone	EUR 355.20 EUR 3168.00 EUR 900.00 EUR 446.40 EUR 234.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), FITC
4-PAC213Mu01-FITC	Cloud-Clone	EUR 361.20 EUR 3254.40 EUR 921.60 EUR 454.80 EUR 236.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Biotinylated
4-PAC213Hu01-Biotin	Cloud-Clone	EUR 373.20 EUR 2952.00 EUR 872.40 EUR 457.20 EUR 262.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Biotinylated
4-PAC213Mu01-Biotin	Cloud-Clone	EUR 379.20 EUR 3031.20 EUR 892.80 EUR 464.40 EUR 265.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC-Cy7
4-PAC213Hu01-APC-Cy7	Cloud-Clone	EUR 685.20 EUR 7716.00 EUR 2046.00 EUR 912.00 EUR 382.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC-Cy7
4-PAC213Mu01-APC-Cy7	Cloud-Clone	EUR 699.60 EUR 7932.00 EUR 2100.00 EUR 933.60 EUR 388.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody
CAU22609-100ul	Biomatik Corporation	100ul	EUR 235.2

Vav 3 Oncogene (VAV3) Polyclonal Antibody
CAU22609-200ul	Biomatik Corporation	200ul	EUR 294

Vav 3 Oncogene (VAV3) Polyclonal Antibody
CAU22610-100ul	Biomatik Corporation	100ul	EUR 235.2

Vav 3 Oncogene (VAV3) Polyclonal Antibody
CAU22610-200ul	Biomatik Corporation	200ul	EUR 294

Vav 1 Oncogene (VAV1) Antibody
abx331549-100ul	Abbexa	100 ul	EUR 510

Vav 1 Oncogene (VAV1) Antibody
abx332110-100ul	Abbexa	100 ul	EUR 510

Vav 1 Oncogene (VAV1) Antibody
20-abx327434	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Vav 1 Oncogene (VAV1) Antibody
20-abx128450	Abbexa	EUR 510.00 EUR 159.60 EUR 1446.00 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Vav 1 Oncogene (VAV1) Antibody
20-abx131502	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Vav 1 Oncogene (VAV1) Antibody
20-abx327966	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Vav 1 Oncogene (VAV1) Antibody
20-abx329103	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)
4-PAE929Hu01	Cloud-Clone	EUR 296.40 EUR 3012.00 EUR 750.00 EUR 372.00 EUR 256.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)
4-PAE929Hu02	Cloud-Clone	EUR 296.40 EUR 3012.00 EUR 750.00 EUR 372.00 EUR 256.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE
4-PAE929Hu01-PE	Cloud-Clone	EUR 355.20 EUR 3168.00 EUR 900.00 EUR 446.40 EUR 234.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE
4-PAE929Hu02-PE	Cloud-Clone	EUR 355.20 EUR 3168.00 EUR 900.00 EUR 446.40 EUR 234.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC
4-PAE929Hu01-APC	Cloud-Clone	EUR 414.00 EUR 3930.00 EUR 1094.40 EUR 528.00 EUR 262.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3
4-PAE929Hu01-Cy3	Cloud-Clone	EUR 502.80 EUR 5190.00 EUR 1410.00 EUR 654.00 EUR 301.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP
4-PAE929Hu01-HRP	Cloud-Clone	EUR 379.20 EUR 3426.00 EUR 968.40 EUR 477.60 EUR 247.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC
4-PAE929Hu02-APC	Cloud-Clone	EUR 414.00 EUR 3930.00 EUR 1094.40 EUR 528.00 EUR 262.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3
4-PAE929Hu02-Cy3	Cloud-Clone	EUR 502.80 EUR 5190.00 EUR 1410.00 EUR 654.00 EUR 301.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP
4-PAE929Hu02-HRP	Cloud-Clone	EUR 379.20 EUR 3426.00 EUR 968.40 EUR 477.60 EUR 247.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC
4-PAE929Hu01-FITC	Cloud-Clone	EUR 355.20 EUR 3168.00 EUR 900.00 EUR 446.40 EUR 234.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC
4-PAE929Hu02-FITC	Cloud-Clone	EUR 355.20 EUR 3168.00 EUR 900.00 EUR 446.40 EUR 234.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7
4-PAE929Hu01-APC-Cy7	Cloud-Clone	EUR 685.20 EUR 7716.00 EUR 2046.00 EUR 912.00 EUR 382.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7
4-PAE929Hu02-APC-Cy7	Cloud-Clone	EUR 685.20 EUR 7716.00 EUR 2046.00 EUR 912.00 EUR 382.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated
4-PAE929Hu01-Biotin	Cloud-Clone	EUR 373.20 EUR 2952.00 EUR 872.40 EUR 457.20 EUR 262.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated
4-PAE929Hu02-Biotin	Cloud-Clone	EUR 373.20 EUR 2952.00 EUR 872.40 EUR 457.20 EUR 262.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Recombinant Vav 1 Oncogene (VAV1)
4-RPC213Hu01	Cloud-Clone	EUR 593.09 EUR 282.00 EUR 1894.08 EUR 711.36 EUR 1302.72 EUR 472.80 EUR 4555.20	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Vav 1 Oncogene expressed in: E.coli

Recombinant Vav 1 Oncogene (VAV1)
4-RPC213Mu01	Cloud-Clone	EUR 576.96 EUR 278.40 EUR 1833.60 EUR 691.20 EUR 1262.40 EUR 462.00 EUR 4404.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Vav 1 Oncogene expressed in: E.coli

Recombinant Vav 1 Oncogene (VAV1)
RPU53092-100ug	Biomatik Corporation	100ug	EUR 542.3

Recombinant Vav 1 Oncogene (VAV1)
RPU53092-1mg	Biomatik Corporation	1mg	EUR 2402.4

Recombinant Vav 1 Oncogene (VAV1)
RPU53092-50ug	Biomatik Corporation	50ug	EUR 435.6

Recombinant Vav 1 Oncogene (VAV1)
RPU52395-100ug	Biomatik Corporation	100ug	EUR 523.6

Recombinant Vav 1 Oncogene (VAV1)
RPU52395-1mg	Biomatik Corporation	1mg	EUR 2320.5

Recombinant Vav 1 Oncogene (VAV1)
RPU52395-50ug	Biomatik Corporation	50ug	EUR 421.3

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody
abx333478-100ul	Abbexa	100 ul	EUR 560.4

Vav 1 Oncogene Phospho-Tyr160 (VAV1 pY160) Antibody
20-abx326674	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody
20-abx327138	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody
20-abx329104	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Mouse Vav 1 Oncogene (VAV1) Protein
20-abx168844	Abbexa	EUR 811.20 EUR 326.40 EUR 2464.80 EUR 961.20 EUR 577.20	100 ug 10 ug 1 mg 200 ug 50 ug

Human Vav 1 Oncogene (VAV1) Protein
20-abx167017	Abbexa	EUR 828.00 EUR 343.20 EUR 2548.80 EUR 978.00 EUR 594.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Vav 1 Oncogene(VAV1) ELISA Kit
QY-E04499	Qayee Biotechnology	96T	EUR 433.2

Human Vav 1 Oncogene (VAV1) ELISA Kit
EKN53099-5x96T	Biomatik Corporation	5x96T	EUR 2346.03

Human Vav 1 Oncogene (VAV1) ELISA Kit
EKN53099-96T	Biomatik Corporation	96T	EUR 493.9

Human Vav 1 Oncogene (VAV1) ELISA Kit
EKU11988-48T	Biomatik Corporation	48T	EUR 555.66

Human Vav 1 Oncogene (VAV1) ELISA Kit
EKU11988-5x96T	Biomatik Corporation	5x96T	EUR 3770.55

Human Vav 1 Oncogene (VAV1) ELISA Kit
EKU11988-96T	Biomatik Corporation	96T