Infectie De temperatuur beïnvloedt het fenotype en functie van chimere  Antigeen  Receptor  T-cellen geproduceerd  by way of  Lentiviral Expertise

Chimere antigeenreceptor (CAR)-T-celtherapie is een belangrijke methode geworden voor de behandeling van hematologische tumoren. Lentivirussen zijn veelgebruikte genoverdrachtsvectoren voor het bereiden van CAR-T-cellen, en de voorwaarden voor het bereiden van CAR-T-cellen variëren sterk. Deze studie rapporteerde voor het eerst de invloed van verschillen in infectietemperatuur op het fenotype en de functie van geproduceerde CAR-T-cellen.

Onze resultaten laten zien dat infectie bij four graden de hoogste CAR-positieve snelheid van T-cellen produceert, infectie bij 37 graden produceert de snelste proliferatie in CAR-T-cellen, en infectie bij 32 graden produceert CAR-T-cellen met het grootste aandeel naïeve cellen en de laagste expressie van immuuncheckpoints. Daarom wordt infectie bij 32 graden aanbevolen om CAR-T-cellen te bereiden. CAR-T-cellen afkomstig van infectie bij 32 graden lijken een balans te hebben tussen functie en fenotype. Belangrijk is dat ze een verhoogd oncolytisch vermogen hebben. Dit onderzoek zal de generatie van CAR-T-cellen helpen optimaliseren en de kwaliteit van CAR-T-celproducten verbeteren.

 

Ontwikkeling van een  antigeen- antilichaam-co-displaysysteem voor het detecteren van interactie van G-eiwit-gekoppelde  receptoren  en variabele fragmenten met één keten

G-proteïne-gekoppelde receptoren (GPCR’s), vooral chemokinereceptoren, zijn ideale doelwitten voor geneesmiddelen met monoklonale antilichamen. Gezien de speciale multi-pass transmembraanstructuur van GPCR, is het vaak een moeizame taak om antilichaaminformatie te verkrijgen over off-targets en epitopen op antigenen. Om het proces te versnellen, moet een snelle en eenvoudige methode worden ontwikkeld. Het op split-ubiquitine gebaseerde gist twee hybride systeem (YTH) werd gebruikt als een blauw script voor een nieuwe methode. Door te fuseren met transmembraanpeptiden, werden scFv-antilichamen ontworpen om te worden verankerd op het cytomembraan, waar ook de GPCR werd getoond. Het gekoppelde split-ubiquitinesysteem transformeerde het scFv-GPCR- interactiesignaal in de expressie van reportergenen.

Door de topologische structuur van scFv-fusie-eiwit en sleutelelementen, waaronder signaalpeptiden, transmembraanpeptiden en flexibele linkers, te optimaliseren , werd een systeem met de naam Antigen-Antibody Co-Show (AACD) opgezet, dat snel de interacties tussen antilichamen en hun doel-GPCR’s detecteerde , CXCR4 en CXCR5, terwijl ook de off-target antilichamen en antilichaam-geassocieerde epitopen worden bepaald. Het AACD-systeem kan snel de associatie tussen GPCR’s en hun kandidaat-antilichamen bepalen en de onderzoeksperiode voor off-target detectie en epitoopidentificatie verkorten. Dit systeem moet het proces van de ontwikkeling van GPCR-antilichamen verbeteren en een nieuwe strategie bieden voor het screenen van GPCR-antilichamen.

Caspase 12 (CASP12) Antibody
20-abx111421	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Caspase 12 (CASP12) Antibody
20-abx100899	Abbexa	EUR 425.00 EUR 133.00 EUR 1177.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Caspase 12 (CASP12) Antibody
abx026563-400ul	Abbexa	400 ul	EUR 523

Caspase 12 (CASP12) Antibody
abx026563-80l	Abbexa	80 µl	EUR 286

Caspase 12 (CASP12) Antibody
20-abx318255	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (Casp12) Antibody
20-abx318989	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (CASP12) Antibody
abx216233-100ug	Abbexa	100 ug	EUR 439

Caspase 12 (CASP12) Antibody
20-abx213378	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Caspase 12 (CASP12) Antibody
20-abx210324	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Caspase 12 (CASP12) Antibody
20-abx324638	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Caspase 12 (CASP12) Polyclonal Antibody (Mouse)
4-PAA682Mu01	Cloud-Clone	EUR 236.00 EUR 2338.00 EUR 586.00 EUR 294.00 EUR 209.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12)

Recombinant Caspase 12 (CASP12)
4-RPA682Mu01	Cloud-Clone	EUR 467.36 EUR 228.00 EUR 1477.60 EUR 559.20 EUR 1018.40 EUR 376.00 EUR 3544.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Caspase 12 expressed in: E.coli

Recombinant Caspase 12 (CASP12)
4-RPA682Ra01	Cloud-Clone	EUR 494.24 EUR 235.00 EUR 1578.40 EUR 592.80 EUR 1085.60 EUR 394.00 EUR 3796.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Caspase 12 expressed in: E.coli

Caspase 12 (Casp12) Antibody (HRP)
20-abx318990	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (Casp12) Antibody (FITC)
20-abx318991	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (Casp12) Antibody (Biotin)
20-abx318992	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (CASP12) Antibody (HRP)
20-abx316303	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (CASP12) Antibody (FITC)
20-abx316304	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (CASP12) Antibody (Biotin)
20-abx316305	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC
4-PAA682Mu01-APC	Cloud-Clone	EUR 329.00 EUR 3041.00 EUR 854.00 EUR 416.00 EUR 212.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Biotinylated
4-PAA682Mu01-Biotin	Cloud-Clone	EUR 299.00 EUR 2288.00 EUR 684.00 EUR 363.00 EUR 214.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Biotin.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), Cy3
4-PAA682Mu01-Cy3	Cloud-Clone	EUR 397.00 EUR 4013.00 EUR 1097.00 EUR 513.00 EUR 241.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), FITC
4-PAA682Mu01-FITC	Cloud-Clone	EUR 283.00 EUR 2452.00 EUR 703.00 EUR 353.00 EUR 189.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), HRP
4-PAA682Mu01-HRP	Cloud-Clone	EUR 302.00 EUR 2652.00 EUR 756.00 EUR 377.00 EUR 200.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), PE
4-PAA682Mu01-PE	Cloud-Clone	EUR 283.00 EUR 2452.00 EUR 703.00 EUR 353.00 EUR 189.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with PE.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat)
4-PAA682Ra01	Cloud-Clone	EUR 243.00 EUR 2457.00 EUR 613.00 EUR 305.00 EUR 212.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12)

Rat Caspase 12 (CASP12) Protein
20-abx065753	Abbexa	EUR 690.00 EUR 286.00 EUR 2124.00 EUR 815.00 EUR 495.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Caspase 12 (CASP12) Protein
20-abx167225	Abbexa	EUR 648.00 EUR 272.00 EUR 1998.00 EUR 773.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug

Caspase 12 (CASP12) Polyclonal Antibody (Mouse), APC-Cy7
4-PAA682Mu01-APC-Cy7	Cloud-Clone	EUR 538.00 EUR 5962.00 EUR 1588.00 EUR 713.00 EUR 304.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Caspase 12 (CASP12). This antibody is labeled with APC-Cy7.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), APC
4-PAA682Ra01-APC	Cloud-Clone	EUR 340.00 EUR 3203.00 EUR 894.00 EUR 432.00 EUR 217.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with APC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), Biotinylated
4-PAA682Ra01-Biotin	Cloud-Clone	EUR 307.00 EUR 2407.00 EUR 714.00 EUR 375.00 EUR 217.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with Biotin.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), Cy3
4-PAA682Ra01-Cy3	Cloud-Clone	EUR 411.00 EUR 4229.00 EUR 1151.00 EUR 535.00 EUR 248.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with Cy3.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), FITC
4-PAA682Ra01-FITC	Cloud-Clone	EUR 292.00 EUR 2582.00 EUR 735.00 EUR 366.00 EUR 194.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with FITC.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), HRP
4-PAA682Ra01-HRP	Cloud-Clone	EUR 311.00 EUR 2792.00 EUR 791.00 EUR 391.00 EUR 205.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with HRP.

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), PE
4-PAA682Ra01-PE	Cloud-Clone	EUR 292.00 EUR 2582.00 EUR 735.00 EUR 366.00 EUR 194.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with PE.

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 349

Human Caspase- 12, CASP12 ELISA KIT
ELI-02372h	Lifescience Market	96 Tests	EUR 824

Mouse Caspase- 12, Casp12 ELISA KIT
ELI-02373m	Lifescience Market	96 Tests	EUR 865

Mouse Caspase 12 (CASP12) ELISA Kit
SEA682Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4862.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids.

Mouse Caspase 12 (CASP12) ELISA Kit
SEA682Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 488.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids.

Mouse Caspase 12 (CASP12) ELISA Kit
SEA682Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 654.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids.

Mouse Caspase 12 (CASP12) ELISA Kit
SEA682Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2644.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Caspase 12 (CASP12) in tissue homogenates, cell lysates and other biological fluids.

Mouse Caspase 12 (CASP12) ELISA Kit
4-SEA682Mu	Cloud-Clone	EUR 4913.00 EUR 2595.00 EUR 655.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Caspase 12 (CASP12) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Caspase 12 (CASP12) ELISA Kit
abx513694-96tests	Abbexa	96 tests	EUR 707

Rat Casp12/ Caspase-12 ELISA Kit
E0156Ra	Sunlong	1 Kit	EUR 571

Mouse Casp12/ Caspase-12 ELISA Kit
E0211Mo	Sunlong	1 Kit	EUR 571

Mouse Caspase 12 (CASP12) CLIA Kit
20-abx491877	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests

Rat Caspase 12 (CASP12) ELISA Kit
abx256323-96tests	Abbexa	96 tests	EUR 786

Mouse Caspase 12 (CASP12) ELISA Kit
20-abx258452	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Human Caspase 12 (CASP12) ELISA Kit
20-abx259273	Abbexa	EUR 6642.00 EUR 3542.00 EUR 825.00	10 × 96 tests 5 × 96 tests 96 tests

Mouse Caspase 12 (CASP12) ELISA Kit
abx254790-96tests	Abbexa	96 tests	EUR 668

Rat Caspase 12 (CASP12) ELISA Kit
abx353550-96tests	Abbexa	96 tests	EUR 786

Human Caspase 12 (CASP12) ELISA Kit
abx358592-96tests	Abbexa	96 tests	EUR 707

Human Caspase 12 (CASP12) CLIA Kit
abx196504-96tests	Abbexa	96 tests	EUR 825

Rat Caspase 12 (CASP12) CLIA Kit
abx196787-96tests	Abbexa	96 tests	EUR 825

Mouse Caspase 12 ELISA Kit (CASP12)
RK02662	Abclonal	96 Tests	EUR 521

Rat Casp12(Caspase 12) ELISA Kit
ER0345	FN Test	96T	EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml

Mouse Casp12(Caspase-12) ELISA Kit
EM0436	FN Test	96T	EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Caspase 12 (CASP12) Polyclonal Antibody (Mouse, Rat), APC-Cy7
4-PAA682Ra01-APC-Cy7	Cloud-Clone	EUR 560.00 EUR 6286.00 EUR 1669.00 EUR 745.00 EUR 315.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caspase 12 (CASP12). This antibody is labeled with APC-Cy7.

ELISA kit for Rat CASP12 (Caspase 12)
E-EL-R0165	Elabscience Biotech	1 plate of 96 wells	EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Rat CASP12 (Caspase 12) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat CASP12 (Caspase 12)
E-CL-R0750	Elabscience Biotech	1 plate of 96 wells	EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Rat CASP12 (Caspase 12) in samples from Serum, Plasma, Cell supernatant

Human CASP12/ Inactive caspase-12 ELISA Kit
E0355Hu	Sunlong	1 Kit	EUR 571

ELISA kit for Mouse CASP12 (Caspase 12)
ELK7681	ELK Biotech	1 plate of 96 wells	EUR 432
Description: A sandwich ELISA kit for detection of Caspase 12 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Rabbit Anti Caspase-12 (Aa100-116) Polyclonal Antibody
CPBT-66303RC	Creative Diagnostics	0.1 mg	EUR 580

Casp12 ELISA Kit| Rat Caspase 12 ELISA Kit
EF017215	Lifescience Market	96 Tests	EUR 689

Casp12 ELISA Kit| Mouse Caspase-12 ELISA Kit
EF013086	Lifescience Market	96 Tests	EUR 689

Caspase 12 (Caspase 12) Antibody
20-abx007974	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul

Caspase 12 (Caspase 12) Antibody
abx432451-200ul	Abbexa	200 ul	EUR 384

Caspase 12 (Caspase 12) Antibody
abx231286-100ug	Abbexa	100 ug	EUR 481

Anti-Caspase 12 antibody
PAab01286	Lifescience Market	100 ug	EUR 355

Anti-Caspase-12 Antibody
A04700	BosterBio	100ug	EUR 471
Description: Rabbit Polyclonal Caspase-12 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

anti- Caspase 12 antibody
FNab01286	FN Test	100µg	EUR 505.25
Description: Antibody raised against Caspase 12

Caspase 12 Polyclonal Antibody
ABP50853-003ml	Abbkine	0.03ml	EUR 158
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody
ABP50853-01ml	Abbkine	0.1ml	EUR 289
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Caspase 12 Polyclonal Antibody
ABP50853-02ml	Abbkine	0.2ml	EUR 414
Description: A polyclonal antibody for detection of Caspase 12 from Human. This Caspase 12 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Caspase12

Polyclonal Caspase-12 Antibody
APR06275G	Leading Biology	0.1 mg	EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody
APR06276G	Leading Biology	0.1 mg	EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody
APR00058G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 . This antibody is tested and proven to work in the following applications:

Caspase-12 Rabbit pAb
A0217-100ul	Abclonal	100 ul	EUR 308

Caspase-12 Rabbit pAb
A0217-200ul	Abclonal	200 ul	EUR 459

Caspase-12 Rabbit pAb
A0217-20ul	Abclonal	20 ul	EUR 183

Caspase-12 Rabbit pAb
A0217-50ul	Abclonal	50 ul	EUR 223

Polyclonal Caspase-12 Antibody (Large)
APR06327G	Leading Biology	0.1 mg	EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Large). This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-12 Antibody (Small)
APR06328G	Leading Biology	0.1 mg	EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-12 (Small). This antibody is tested and proven to work in the following applications:

Anti-CASP12 antibody
STJ112891	St John's Laboratory	100 µl	EUR 277

Casp12 Polyclonal Antibody
A50097	EpiGentek	100 µg	EUR 570.55
Description: fast delivery possible

Caspase 12 antibody
70R-51166	Fitzgerald	100 ul	EUR 244
Description: Purified Polyclonal Caspase 12 antibody

Caspase 12 antibody
20R-1513	Fitzgerald	100 ug	EUR 673
Description: Rabbit polyclonal Caspase 12 antibody

Caspase 12 antibody
70R-11740	Fitzgerald	100 ug	EUR 460
Description: Rabbit polyclonal Caspase 12 antibody

Caspase-12 Antibody
3282-100	Biovision		EUR 354

Caspase-12 Antibody
3282-30T	Biovision		EUR 146

Caspase-12 Antibody
24119-100ul	SAB	100ul	EUR 390

Caspase-12 Antibody
24120-100ul	SAB	100ul	EUR 390

Rabbit Caspase 12 ELISA kit
E04C0690-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase 12 ELISA kit
E04C0690-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase 12 ELISA kit
E04C0690-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Caspase-12 ELISA Kit
ERTC0697	Abclonal	96Tests	EUR 521

Human cysteinyl aspartate specific proteinases 12,Caspase-12 ELISA Kit
201-12-0763	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Caspase-12
RA15048	Neuromics	100 ug	EUR 461

Anti-Caspase 12 (aa232-244) antibody
STJ72856	St John's Laboratory	100 µg	EUR 359

Caspase-12 Antibody (Large)
24208-100ul	SAB	100ul	EUR 390

Caspase-12 Antibody (Small)
24209-100ul	SAB	100ul	EUR 390

Rabbit Anti Human Caspase-2 Polyclonal Antibody
CPBT-66277RH	Creative Diagnostics	50 µg	EUR 985

Rabbit Anti Human Caspase-3 Polyclonal Antibody
CPBT-66278RH	Creative Diagnostics	10 µl*	EUR 429

Rabbit Anti Human Caspase-3 Polyclonal Antibody
CPBT-66279RH	Creative Diagnostics	0.1 ml	EUR 767

Rabbit Anti Human Caspase-5 Polyclonal Antibody
CPBT-66285RH	Creative Diagnostics	0.1 mg	EUR 580

CASP12 antibody
70R-16177	Fitzgerald	50 ul	EUR 435
Description: Rabbit polyclonal CASP12 antibody

CASP12 Antibody
1-CSB-PA041334	Cusabio	EUR 317.00 EUR 244.00	100ul 50ul
Description: A polyclonal antibody against CASP12. Recognizes CASP12 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

CASP12 Antibody
1-CSB-PA291244	Cusabio	EUR 317.00 EUR 244.00	100ul 50ul
Description: A polyclonal antibody against CASP12. Recognizes CASP12 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200

CASP12 Antibody
1-CSB-PA747641LA01HU	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against CASP12. Recognizes CASP12 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

CASP12 Antibody
1-CSB-PA001229	Cusabio	EUR 222.00 EUR 195.00	100ug 50ug
Description: A polyclonal antibody against CASP12. Recognizes CASP12 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000

CASP12 Antibody
1-CSB-PA004545GA01HU	Cusabio	EUR 597.00 EUR 333.00	150ul 50ul
Description: A polyclonal antibody against CASP12. Recognizes CASP12 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB

Casp12 Antibody
1-CSB-PA004545LA01MO	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against Casp12. Recognizes Casp12 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

CASP12 Antibody
36777-100ul	SAB	100ul	EUR 252

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 280

Casp12 Polyclonal Antibody, HRP Conjugated
A50098	EpiGentek	100 µg	EUR 570.55
Description: reagents widely cited

Casp12 Polyclonal Antibody, FITC Conjugated
A50099	EpiGentek	100 µg	EUR 570.55
Description: Ask the seller for details

Casp12 Polyclonal Antibody, Biotin Conjugated
A50100	EpiGentek	100 µg	EUR 570.55
Description: The best epigenetics products

Rabbit Anti Caspase-4 (N-Terminal) Polyclonal Antibody
CPBT-66281RC	Creative Diagnostics	50 µg	EUR 663

Rabbit Anti Caspase-4 (N-Terminal) Polyclonal Antibody
CPBT-66282RC	Creative Diagnostics	0.1 mg	EUR 710

Rabbit Anti Caspase-7 (N-Terminal) Polyclonal Antibody
CPBT-66291RC	Creative Diagnostics	0.1 mg	EUR 663

Rabbit Anti Caspase-14 (C-Terminal) Polyclonal Antibody
CPBT-66307RC	Creative Diagnostics	0.1 mg	EUR 710

Rabbit Anti G Protein Alpha 12 Polyclonal Antibody
CPBT-67903RG	Creative Diagnostics	1 ml	EUR 663

Caspase 12 Blocking Peptide
33R-10465	Fitzgerald	50 ug	EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 20R-1513

Caspase 12 Blocking Peptide
33R-10701	Fitzgerald	50 ug	EUR 191
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Caspase 12 antibody, catalog no. 70R-11740

Caspase-12 Blocking Peptide
3282BP-50	Biovision		EUR 153

Caspase 12 Assay Kit
55R-1290	Fitzgerald	25 assays	EUR 328
Description: Assay Kit for detection of Capase 12 activity in the research laboratory

Caspase 12 Blocking Peptide
20-abx064041	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg

99445-12 DCT 12 X 75MM
99445-12	CORNING	250/pk	EUR 67
Description: Disposable Culture Tubes; DCT's, CGW

Anti-Caspase-3 Rabbit Monoclonal Antibody
A1120-50	Biovision		EUR 359

Anti-Caspase-8 Rabbit Monoclonal Antibody
M00042	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-8 Antibody. Validated in WB and tested in Human.

Anti-Caspase-8 Rabbit Monoclonal Antibody
M00042-1	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-8 Antibody. Validated in IF, WB and tested in Human.

Anti-Caspase-8 Rabbit Monoclonal Antibody
M00042-2	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-8 Antibody. Validated in ICC/IF, WB and tested in Human.

Anti-Caspase-1 Rabbit Monoclonal Antibody
M00048	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-1 Antibody. Validated in IHC, WB and tested in Human, Rat.

Anti-Caspase-9 Rabbit Monoclonal Antibody
M00080	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-9 Antibody. Validated in WB and tested in Human, Mouse.

Anti-Caspase-9 Rabbit Monoclonal Antibody
M00080-3	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-9 Antibody. Validated in IP, IF, IHC, WB and tested in Human.

Anti-Caspase-3 Rabbit Monoclonal Antibody
M00334-5	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-3 Antibody. Validated in IP, IF, IHC, WB and tested in Human, Rat.

Anti-Caspase-7 Rabbit Monoclonal Antibody
M01044-1	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-7 Antibody. Validated in IP, WB and tested in Mouse, Rat.

Anti-Caspase-10 Rabbit Monoclonal Antibody
M02190-1	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-10 Antibody. Validated in IP, WB and tested in Human.

Anti-Caspase-2 Rabbit Monoclonal Antibody
M02384	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-2 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Caspase-2 Rabbit Monoclonal Antibody
M02384-1	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-2 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Caspase-6 Rabbit Monoclonal Antibody
M02631	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-6 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-Caspase-6 Rabbit Monoclonal Antibody
M02631-2	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-6 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-Caspase-14 Rabbit Monoclonal Antibody
M05143	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase-14 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-Caspase 5 Rabbit Monoclonal Antibody
M05259	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Caspase 5 Antibody. Validated in IP, IF, IHC, ICC, WB and tested in Human.

Casp12/ Rat Casp12 ELISA Kit
ELI-02374r	Lifescience Market	96 Tests	EUR 886

Rabbit Anti Human Caspase-1 (C-Terminal) Polyclonal Antibody
CPBT-66276RH	Creative Diagnostics	0.1 mg	EUR 892

Human Caspase 12,Casp-12 ELISA Kit
CN-03708H1	ChemNorm	96T	EUR 486

Human Caspase 12,Casp-12 ELISA Kit
CN-03708H2	ChemNorm	48T	EUR 336

Anti Keratin 12 Polyclonal Antibody
KR074	Sceti		EUR 649
Description: The Anti Keratin 12 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.

CASP12 Conjugated Antibody
C36777	SAB	100ul	EUR 397

Rabbit Anti-Human CAV1 (aa 12-16) Polyclonal Antibody
CPB-1020RH	Creative Diagnostics	100 ul	EUR 460

Caspase 12 ELISA KIT|Human
EF008399	Lifescience Market	96 Tests	EUR 689

Human Caspase 12 ELISA kit
E01C0690-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caspase 12 ELISA kit
E01C0690-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caspase 12 ELISA kit
E01C0690-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 12 ELISA kit
E03C0690-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 12 ELISA kit
E03C0690-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase 12 ELISA kit
E03C0690-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 12 ELISA kit
E02C0690-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 12 ELISA kit
E02C0690-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caspase 12 ELISA kit
E02C0690-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caspase-12 Substrate ATAD-AFC
1117-1000	Biovision		EUR 1088

Caspase-12 Substrate ATAD-AFC
1117-200	Biovision		EUR 436

Pig Caspase 12 ELISA kit
E07C0690-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 12 ELISA kit
E07C0690-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caspase 12 ELISA kit
E07C0690-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 12 ELISA kit
E08C0690-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 12 ELISA kit
E08C0690-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caspase 12 ELISA kit
E08C0690-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 12 ELISA kit
E06C0690-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 12 ELISA kit
E06C0690-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caspase 12 ELISA kit
E06C0690-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caspase-12 Fluorometric Assay Kit
K139-100	Biovision		EUR 501

Caspase-12 Fluorometric Assay Kit
K139-25	Biovision		EUR 256

Monkey Caspase 12 ELISA kit
E09C0690-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 12 ELISA kit
E09C0690-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Caspase 12 ELISA kit
E09C0690-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Caspase 12 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caspase-12 ELISA Kit
EMC0697	Abclonal	96Tests	EUR 521

Porcine Caspase-12 ELISA Kit
EPC0697	Abclonal	96Tests	EUR 521

Rat Caspase-12 ELISA Kit
ERC0697	Abclonal	96Tests	EUR 521

Anserini Caspase-12 ELISA Kit
EAC0697	Abclonal	96Tests	EUR 521

Goat Caspase-12 ELISA Kit
EGTC0697	Abclonal	96Tests	EUR 521

Canine Caspase-12 ELISA Kit
ECC0697	Abclonal	96Tests	EUR 521

Human Caspase-12 ELISA Kit
EHC0697	Abclonal	96Tests	EUR 521

Bovine Caspase-12 ELISA Kit
EBC0697	Abclonal	96Tests	EUR 521

Caspase-12 Fluorometric Assay Kit
K2150-100	ApexBio	100 assays	EUR 529

Caspase-12 Fluorometric Assay Kit
K2150-25	ApexBio	25 assays	EUR 251

CASP12 siRNA
20-abx900800	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

CASP12 siRNA
20-abx910329	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

CASP12 siRNA
20-abx910330	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

Anti-pro Caspase 9 Rabbit Monoclonal Antibody
M00080-1	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal pro Caspase 9 Antibody. Validated in WB and tested in Human.

Anti-cleaved Caspase-9 Rabbit Monoclonal Antibody
M00080-2	BosterBio	100ug/vial	EUR 397
Description: Anti-cleaved Caspase-9 Rabbit Monoclonal Antibody tested for IP, WB in Human, Mouse

Ontwikkeling van een  antigeen- antilichaam-co-displaysysteem voor het detecteren van interactie van G-eiwit-gekoppelde  receptoren  en variabele fragmenten met één keten

G-proteïne-gekoppelde receptoren (GPCR’s), vooral chemokinereceptoren, zijn ideale doelwitten voor geneesmiddelen met monoklonale antilichamen. Gezien de speciale multi-pass transmembraanstructuur van GPCR, is het vaak een moeizame taak om antilichaaminformatie te verkrijgen over off-targets en epitopen op antigenen. Om het proces te versnellen, moet een snelle en eenvoudige methode worden ontwikkeld . Het op split-ubiquitine gebaseerde gist twee hybride systeem (YTH) werd gebruikt als een blauw script voor een nieuwe methode. Door te fuseren met transmembraanpeptiden, werden scFv-antilichamen ontworpen om te worden verankerd op het cytomembraan, waar ook de GPCR werd getoond. Het gekoppelde split-ubiquitinesysteem transformeerde het scFv-GPCR-interactiesignaal in de expressie van reportergenen.

Door de topologische structuur van scFv- fusie-eiwit en sleutelelementen, waaronder signaalpeptiden, transmembraanpeptiden en flexibele linkers, te optimaliseren , werd een systeem met de naam Antigen-Antibody Co-Show (AACD) opgezet, dat snel de interacties tussen antilichamen en hun doel-GPCR’s detecteerde , CXCR4 en CXCR5, terwijl ook de off-target antilichamen en antilichaam-geassocieerde epitopen worden bepaald. Het AACD-systeem kan snel de associatie tussen GPCR’s en hun kandidaat-antilichamen bepalen en de onderzoeksperiode voor off-target detectie en epitoopidentificatie verkorten. Dit systeem moet het proces van de ontwikkeling van GPCR-antilichamen verbeteren en een nieuwe strategie bieden voor het screenen van GPCR-antilichamen.

Chimere  Antigeen  Receptor -gemodificeerde T-cellen en T-Cell Partaking Bispecifieke antilichamen: Verschillende Hulpmiddelen voor hetzelfde werk

Doel van de beoordeling:  Zowel chimere antigeenreceptor (CAR) T-cellen als T-cel-aangrijpende antilichamen (BiAb) zijn goedgekeurd voor de behandeling van hematologische maligniteiten. Ondanks dat ze zich op hetzelfde antigeen richten, vertegenwoordigen ze echter zeer verschillende klassen van therapieën, elk met zijn duidelijke voor- en nadelen. In deze evaluation vergelijken we BiAb- en CAR T-cellen met betrekking tot hun werkingsmechanisme, productie en klinische toepassing. Daarnaast presenteren we nieuwe strategieën om de beperkingen van beide benaderingen te overwinnen en het beste van beide werelden te combineren.

Recente bevindingen:  Inmiddels zijn er meerdere benaderingen die de voordelen van BiAb en CAR T-cellen combineren. Een belangrijk onderzoeksgebied is de toepassing van beide formaten voor solide tumorentiteiten. Dit omvat het verbeteren van de infiltratie van T-cellen in de tumor, het tegengaan van immunosuppressie in de micro-omgeving van de tumor, het richten op antigeenheterogeniteit en het beperken van off-tumor on-target effecten . BiAb heeft het grote voordeel dat het een kant-en-klaar product is en beter controleerbaar is vanwege hun halfwaardetijd. Er is ook gemeld dat ze minder frequente en minder ernstige bijwerkingen veroorzaken. CAR T-cellen vertonen op hun beurt superieure responspercentages, hebben het potentieel voor persistentie op de lange termijn en kunnen bovendien genetisch worden gemodificeerd om bepaalde problemen te overwinnen. van hun beperkingen, bijvoorbeeld om ze beter beheersbaar te maken.

Chimeer  antigen  receptor  pure killer (CAR-NK) cel ontwerp en engineering voor kankertherapie

Vanwege hun efficiënte herkenning en lysis van kwaadaardige cellen , worden pure killer (NK)-cellen beschouwd als gespecialiseerde immuuncellen die genetisch kunnen worden gemodificeerd om capabele effectorcellen te verkrijgen voor adoptieve cellulaire behandeling van kankerpatiënten. Biologische en technische hindernissen met betrekking tot genafgifte in NK-cellen hebben de vooruitgang echter dramatisch beperkt. Recente technologische ontwikkelingen, waaronder verbeterde celexpansietechnieken, chimere antigeenreceptoren (CAR) , CRISPR/Cas9-genediting en verbeterde virale transductie en elektroporatie, hebben een uitgebreide generatie en karakterisering van genetisch gemodificeerde NK-cellen mogelijk gemaakt. Deze veelbelovende ontwikkelingen helpen wetenschappers en artsen om betere toepassingen van NK-cellen in de klinische praktijk te ontwerpentherapie. Met identify het omleiden van NK-cellen met behulp van CAR’s houdt een belangrijke belofte in voor immunotherapie van kanker.

Various preklinische en een beperkt aantal klinische onderzoeken met CAR-NK- cellen laten veelbelovende resultaten zien: efficiënte eliminatie van doelcellen zonder bijwerkingen, zoals cytokine-release-syndroom en neurotoxiciteit die worden gezien bij CAR-T-therapieën. In deze evaluation concentreren we ons op de particulars van CAR-NK-technologie, inclusief het ontwerp van efficiënte en veilige CAR-constructies en bijbehorende NK-cel-engineeringtechnieken: de voertuigen om het CAR-bevattende transgen af te leveren., detectiemethoden voor CAR’s, evenals NK-celbronnen en NK-celexpansie. We vatten de huidige literatuur over CAR-NK-cellen samen en omvatten waardevolle reduce die zijn geleerd uit het CAR-T-celveld. Deze beoordeling biedt ook een kijk op hoe deze benaderingen de huidige klinische producten en protocollen voor de behandeling van kanker kunnen transformeren.

 

Recombinant Vav 1 Oncogene (VAV1)
4-RPC213Mu01	Cloud-Clone	EUR 480.80 EUR 232.00 EUR 1528.00 EUR 576.00 EUR 1052.00 EUR 385.00 EUR 3670.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Vav 1 Oncogene expressed in: E.coli

Proto-Oncogene Vav (VAV1) Antibody
abx011903-100ug	Abbexa	100 ug	EUR 411

Proto-Oncogene Vav (VAV1) Antibody
20-abx012888	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg

Proto-Oncogene Vav (VAV1) Antibody
20-abx000854	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul

Proto-Oncogene Vav (VAV1) Antibody
abx239377-100ug	Abbexa	100 ug	EUR 551

Proto-Oncogene Vav (VAV1) Antibody
20-abx141277	Abbexa	EUR 356.00 EUR 537.00 EUR 217.00	100 ul 200 ul 30 ul

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC
4-PAC213Hu01-APC	Cloud-Clone	EUR 345.00 EUR 3275.00 EUR 912.00 EUR 440.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Biotinylated
4-PAC213Hu01-Biotin	Cloud-Clone	EUR 311.00 EUR 2460.00 EUR 727.00 EUR 381.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Cy3
4-PAC213Hu01-Cy3	Cloud-Clone	EUR 419.00 EUR 4325.00 EUR 1175.00 EUR 545.00 EUR 251.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), FITC
4-PAC213Hu01-FITC	Cloud-Clone	EUR 296.00 EUR 2640.00 EUR 750.00 EUR 372.00 EUR 195.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), HRP
4-PAC213Hu01-HRP	Cloud-Clone	EUR 316.00 EUR 2855.00 EUR 807.00 EUR 398.00 EUR 206.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), PE
4-PAC213Hu01-PE	Cloud-Clone	EUR 296.00 EUR 2640.00 EUR 750.00 EUR 372.00 EUR 195.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC
4-PAC213Mu01-APC	Cloud-Clone	EUR 351.00 EUR 3365.00 EUR 935.00 EUR 449.00 EUR 222.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Biotinylated
4-PAC213Mu01-Biotin	Cloud-Clone	EUR 316.00 EUR 2526.00 EUR 744.00 EUR 387.00 EUR 221.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Cy3
4-PAC213Mu01-Cy3	Cloud-Clone	EUR 427.00 EUR 4445.00 EUR 1205.00 EUR 557.00 EUR 254.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), FITC
4-PAC213Mu01-FITC	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), HRP
4-PAC213Mu01-HRP	Cloud-Clone	EUR 321.00 EUR 2933.00 EUR 827.00 EUR 405.00 EUR 209.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), PE
4-PAC213Mu01-PE	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Mouse Vav 1 Oncogene (VAV1) Protein
20-abx168844	Abbexa	EUR 676.00 EUR 272.00 EUR 2054.00 EUR 801.00 EUR 481.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Vav 1 Oncogene (VAV1) Protein
20-abx167017	Abbexa	EUR 690.00 EUR 286.00 EUR 2124.00 EUR 815.00 EUR 495.00	100 ug 10 ug 1 mg 200 ug 50 ug

Proto-Oncogene Vav (VAV1) Protein
20-abx263391	Abbexa	EUR 1609.00 EUR 328.00 EUR 230.00	100 ug 10 ug 2 µg

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC-Cy7
4-PAC213Hu01-APC-Cy7	Cloud-Clone	EUR 571.00 EUR 6430.00 EUR 1705.00 EUR 760.00 EUR 319.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC-Cy7
4-PAC213Mu01-APC-Cy7	Cloud-Clone	EUR 583.00 EUR 6610.00 EUR 1750.00 EUR 778.00 EUR 324.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Human Vav 1 Oncogene(VAV1) ELISA Kit
QY-E04499	Qayee Biotechnology	96T	EUR 361

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody
abx333478-100ul	Abbexa	100 ul	EUR 467

Vav 1 Oncogene Phospho-Tyr160 (VAV1 pY160) Antibody
20-abx326674	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody
20-abx327138	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody
20-abx329104	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Proto-Oncogene Vav (VAV1) ELISA Kit
abx595617-96tests	Abbexa	96 tests	EUR 637

Mouse Proto- oncogene vav, Vav1 ELISA KIT
ELI-17706m	Lifescience Market	96 Tests	EUR 865

Bovine Proto- oncogene vav, VAV1 ELISA KIT
ELI-51386b	Lifescience Market	96 Tests	EUR 928

Human Proto- oncogene vav, VAV1 ELISA KIT
ELI-51387h	Lifescience Market	96 Tests	EUR 824

Human Proto-oncogene vav (VAV1) ELISA Kit
abx384219-96tests	Abbexa	96 tests	EUR 911

Proto-Oncogene Vav Phospho-Tyr174 (VAV1 pY174) Antibody
20-abx012571	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 349

Anti-VAV1 Antibody
A00691-1	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for VAV1 Antibody (VAV1) detection. Tested with WB in Human, Mouse, Rat.

Rabbit VAV1 oncogene ELISA kit
E04V0079-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit
E04V0079-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit
E04V0079-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)
4-PAE929Hu01	Cloud-Clone	EUR 247.00 EUR 2510.00 EUR 625.00 EUR 310.00 EUR 214.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)
4-PAE929Hu02	Cloud-Clone	EUR 247.00 EUR 2510.00 EUR 625.00 EUR 310.00 EUR 214.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Antibody
20-abx133365	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul

Vav 3 Oncogene (VAV3) Antibody
20-abx101251	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Vav 3 Oncogene (VAV3) Antibody
20-abx101252	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Vav 3 Oncogene (VAV3) Antibody
abx433439-200ul	Abbexa	200 ul	EUR 384

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 280

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC
4-PAE929Hu01-APC	Cloud-Clone	EUR 345.00 EUR 3275.00 EUR 912.00 EUR 440.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated
4-PAE929Hu01-Biotin	Cloud-Clone	EUR 311.00 EUR 2460.00 EUR 727.00 EUR 381.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3
4-PAE929Hu01-Cy3	Cloud-Clone	EUR 419.00 EUR 4325.00 EUR 1175.00 EUR 545.00 EUR 251.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC
4-PAE929Hu01-FITC	Cloud-Clone	EUR 296.00 EUR 2640.00 EUR 750.00 EUR 372.00 EUR 195.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP
4-PAE929Hu01-HRP	Cloud-Clone	EUR 316.00 EUR 2855.00 EUR 807.00 EUR 398.00 EUR 206.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE
4-PAE929Hu01-PE	Cloud-Clone	EUR 296.00 EUR 2640.00 EUR 750.00 EUR 372.00 EUR 195.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC
4-PAE929Hu02-APC	Cloud-Clone	EUR 345.00 EUR 3275.00 EUR 912.00 EUR 440.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated
4-PAE929Hu02-Biotin	Cloud-Clone	EUR 311.00 EUR 2460.00 EUR 727.00 EUR 381.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3
4-PAE929Hu02-Cy3	Cloud-Clone	EUR 419.00 EUR 4325.00 EUR 1175.00 EUR 545.00 EUR 251.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC
4-PAE929Hu02-FITC	Cloud-Clone	EUR 296.00 EUR 2640.00 EUR 750.00 EUR 372.00 EUR 195.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP
4-PAE929Hu02-HRP	Cloud-Clone	EUR 316.00 EUR 2855.00 EUR 807.00 EUR 398.00 EUR 206.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE
4-PAE929Hu02-PE	Cloud-Clone	EUR 296.00 EUR 2640.00 EUR 750.00 EUR 372.00 EUR 195.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Recombinant Vav 3 Oncogene (VAV3)
4-RPE929Hu01	Cloud-Clone	EUR 816.80 EUR 322.00 EUR 2788.00 EUR 996.00 EUR 1892.00 EUR 610.00 EUR 6820.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Recombinant Vav 3 Oncogene (VAV3)
4-RPE929Hu02	Cloud-Clone	EUR 816.80 EUR 322.00 EUR 2788.00 EUR 996.00 EUR 1892.00 EUR 610.00 EUR 6820.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Anti-Vav antibody
STJ96227	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Vav.

Vav Polyclonal Antibody
ES7488-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Vav Polyclonal Antibody
ES7488-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Vav Polyclonal Antibody
ABP56489-003ml	Abbkine	0.03ml	EUR 158
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Vav Polyclonal Antibody
ABP56489-01ml	Abbkine	0.1ml	EUR 289
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Vav Polyclonal Antibody
ABP56489-02ml	Abbkine	0.2ml	EUR 414
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Rabbit Anti-Human Vav1 Polyclonal Antibody, Phospho-Tyr174
CPB-700RH	Creative Diagnostics	100 ul	EUR 559

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7
4-PAE929Hu01-APC-Cy7	Cloud-Clone	EUR 571.00 EUR 6430.00 EUR 1705.00 EUR 760.00 EUR 319.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7
4-PAE929Hu02-APC-Cy7	Cloud-Clone	EUR 571.00