unitech-europe

eiwitten  door capillaire elektroforese van mobiliteit en natieve massaspectrometrie

Snel opkomende SARS-CoV-2 B.1.1.7 sub-lijn in de Verenigde Staten van Amerika met spike  eiwit  D178H en membraan  eiwit  V70L mutaties

 

Samenvatting De SARS-CoV-2 B.1.1.7-afstamming is zeer besmettelijk en was vanaf april 2021 goed voor 92% van de COVID-19-gevallen in Europa en 59% van de COVID-19-gevallen in de VS. Het wordt gedefinieerd door de N501Y-mutatie in het receptorbindende domein (RBD) van het Spike (S)-eiwit en enkele andere mutaties. Deze omvatten twee mutaties in het N-terminale domein (NTD)van het S-eiwit, HV69-70del en Y144del (ook bekend als Y145del vanwege de aanwezigheid van tyrosine op beide posities). We hebben onlangs verschillende opkomende SARS-CoV-2-varianten van problemen geïdentificeerd, gekenmerkt door membraan (M) -eiwitmutaties, waaronder I82T en V70L. We identificeren nu een sublijn van B.1.1.7 die ontstond door opeenvolgende acquisities van M:V70L in november 2020, gevolgd door een nieuwe S:D178H-mutatie die voor het eerst werd waargenomen start februari 2021.

 

Het proportion B.1.1.7-isolaten in de VS dat tot deze sublijn behoort, is gestegen van 0,15% in februari 2021 tot 1,8% in april 2021. Tot op heden lijkt deze sublijn specifiek voor de VS te zijn met gemelde gevallen in 31 staten, waaronder Hawaï. Vanaf april 2021 vormde het 36,8% van alle B.1.1.7-isolaten in Washington. Fylogenetische analyse en transmissie-inferentie met Nextstrain suggereert dat deze sublijn waarschijnlijk afkomstig is uit Californië of Washington . Structurele analyse onthulde dat de S:D178H-mutatie zich in de NTD van het S-eiwit bevindt en dicht bij twee andere kenmerkende mutaties van B.1.1.7, HV69-70del en Y144del. Het is aan het oppervlak blootgesteld en kan de tertiaire configuratie of toegankelijkheid van NTD veranderen, en heeft dus het potentieel om neutralisatie door NTD-gerichte antilichamen te beïnvloeden.

 

Snelle driedimensionale vormbepaling van bolvormige  eiwitten  door capillaire elektroforese van mobiliteit en natieve massaspectrometrie

Gevestigde proteomics-methoden met hoge doorvoer bieden beperkte informatie over de stereostructuren van eiwitten. Traditionele technologieën voor het bepalen van de eiwitstructuur vereisen doorgaans moeizame stappen en kunnen niet op een high-throughput-manier worden uitgevoerd. Hier rapporteren we een nieuwe medium throughput-methode door mobiliteit capillaire elektroforese (MCE) en native massaspectrometrie (MS) te combineren voor de 3-dimensionale (3D) vormbepaling van bolvormige eiwitten in de vloeibare fase , die zowel de geometrische structuur als de moleculaire massa-informatie van eiwitten.

Er werd een theorie ontwikkeld om de hydrodynamische straal van ionen en de verdeling van de ladingstoestand in het natieve massaspectrum te correleren met geometrische eiwitparameters, waardoor een lage-resolutiestructuur (vorm) van het eiwit kon worden bepaald. Onze testgegevens van 11 verschillende globulaire eiwitten toonden aan dat deze benadering ons in staat stelt om de vormen van individuele eiwitten, eiwitcomplexen en eiwitten in een mengsel te bepalen en om veranderingen in eiwitconformatie te volgen. Naast het verstrekken van aanvullende informatie over de eiwitstructuur en het vermogen om mengsels te analyseren, is deze op MCE en native MS gebaseerde methode snel in snelheid en laag in monsterconsumptie, waardoor deze mogelijk toepasbaar is in top-down proteomics en structurele biologie voor intacte globulaire eiwit- of eiwitcomplexanalyse.

unitech-europe
unitech-europe

Pim-2 Oncogene (PIM2) Polyclonal Antibody

CAU21185-200ul 200ul
EUR 351.1

Pim-2 Oncogene (PIM2) Polyclonal Antibody

CAU21186-100ul 100ul
EUR 265.9

Pim-2 Oncogene (PIM2) Polyclonal Antibody

CAU21186-200ul 200ul
EUR 332.6

Pim-2 Oncogene (PIM2) Polyclonal Antibody

CAU21187-100ul 100ul
EUR 259.2

Pim-2 Oncogene (PIM2) Polyclonal Antibody

CAU21187-200ul 200ul
EUR 324.2

Polyclonal Antibody to Pim-2 Oncogene (PIM2)

PAP797Hu01 100ul
EUR 270

Polyclonal Antibody to Pim-2 Oncogene (PIM2)

PAP797Mu01 100ul
EUR 277

Polyclonal Antibody to Pim-2 Oncogene (PIM2)

PAP797Ra01 100ul
EUR 293

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat)

4-PAP797Ra01
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Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2)

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human)

4-PAP797Hu01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2)

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse)

4-PAP797Mu01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2)

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), PE

4-PAP797Ra01-PE
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Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with PE.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), APC

4-PAP797Ra01-APC
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Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with APC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), Cy3

4-PAP797Ra01-Cy3
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Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with Cy3.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), HRP

4-PAP797Ra01-HRP
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Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with HRP.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), PE

4-PAP797Hu01-PE
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Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with PE.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), PE

4-PAP797Mu01-PE
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Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with PE.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), FITC

4-PAP797Ra01-FITC
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Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with FITC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), APC

4-PAP797Hu01-APC
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Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with APC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), Cy3

4-PAP797Hu01-Cy3
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Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with Cy3.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), HRP

4-PAP797Hu01-HRP
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Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with HRP.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), APC

4-PAP797Mu01-APC
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Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with APC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), Cy3

4-PAP797Mu01-Cy3
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with Cy3.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), HRP

4-PAP797Mu01-HRP
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Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with HRP.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), FITC

4-PAP797Hu01-FITC
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Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with FITC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), FITC

4-PAP797Mu01-FITC
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Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with FITC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), Biotinylated

4-PAP797Ra01-Biotin
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Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with Biotin.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), Biotinylated

4-PAP797Hu01-Biotin
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Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with Biotin.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), Biotinylated

4-PAP797Mu01-Biotin
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Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with Biotin.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), APC-Cy7

4-PAP797Ra01-APC-Cy7
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Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with APC-Cy7.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), APC-Cy7

4-PAP797Hu01-APC-Cy7
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Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with APC-Cy7.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), APC-Cy7

4-PAP797Mu01-APC-Cy7
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Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody

CAU24100-100ul 100ul
EUR 255.4

Pim-1 Oncogene (PIM1) Polyclonal Antibody

CAU24100-200ul 200ul
EUR 319.2

Pim-1 Oncogene (PIM1) Polyclonal Antibody

CAU24101-100ul 100ul
EUR 241.9

Pim-1 Oncogene (PIM1) Polyclonal Antibody

CAU24101-200ul 200ul
EUR 302.4

Pim-1 Oncogene (PIM1) Polyclonal Antibody

CAU24102-100ul 100ul
EUR 235.2

Pim-1 Oncogene (PIM1) Polyclonal Antibody

CAU24102-200ul 200ul
EUR 294

Pim-3 Oncogene (PIM3) Polyclonal Antibody

CAU21250-100ul 100ul
EUR 259.2

Pim-3 Oncogene (PIM3) Polyclonal Antibody

CAU21250-200ul 200ul
EUR 324.2

Pim-2 Oncogene (PIM2) Antibody

abx433133-200ul 200 ul
EUR 460.8

Pim-2 Oncogene (PIM2) Antibody

abx433134-200ul 200 ul
EUR 460.8

Pim-2 Oncogene (PIM2) Antibody

abx431508-200ul 200 ul
EUR 460.8

Pim-2 Oncogene (PIM2) Antibody

20-abx101236
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Pim-2 Oncogene (PIM2) Antibody

20-abx101237
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Pim-2 Oncogene (PIM2) Antibody

20-abx129066
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Pim-2 Oncogene (PIM2) Antibody

20-abx174067
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Pim-2 Oncogene (PIM2) Antibody

abx236456-100ug 100 ug
EUR 661.2

Pim-2 Oncogene (PIM2) Antibody

abx236456-100g 100 µg
EUR 350

Pim-2 Oncogene (PIM2) Antibody

abx129066-100l 100 µl
EUR 287.5

Pim-2 Oncogene (PIM2) Antibody

abx129066-1ml 1 ml
EUR 825

Pim-2 Oncogene (PIM2) Antibody

abx129066-200l 200 µl
EUR 362.5

Pim-2 Oncogene (PIM2) Antibody

abx101236-100l 100 µl
EUR 287.5

Pim-2 Oncogene (PIM2) Antibody

abx101236-1ml 1 ml
EUR 850

Pim-2 Oncogene (PIM2) Antibody

abx101236-200l 200 µl
EUR 375

Pim-2 Oncogene (PIM2) Antibody

abx101237-100l 100 µl
EUR 300

Pim-2 Oncogene (PIM2) Antibody

abx101237-1ml 1 ml
EUR 900

Pim-2 Oncogene (PIM2) Antibody

abx101237-200l 200 µl
EUR 387.5

Pim-2 Oncogene (PIM2) Antibody

abx174067-100l 100 µl
EUR 875

Pim-2 Oncogene (PIM2) Antibody

abx174067-1ml 1 ml Ask for price

Pim-2 Oncogene (PIM2) Antibody

abx174067-200l 200 µl Ask for price

Pim-2 Oncogene (PIM2) Antibody

abx431508-200l 200 µl
EUR 387.5

Pim-2 Oncogene (PIM2) Antibody

abx433133-100g 100 µg
EUR 387.5

Pim-2 Oncogene (PIM2) Antibody

abx433134-100g 100 µg
EUR 387.5

Polyclonal Antibody to Pim-1 Oncogene (PIM1)

PAC578Hu01 100ul
EUR 245

Polyclonal Antibody to Pim-1 Oncogene (PIM1)

PAC578Mu01 100ul
EUR 252

Polyclonal Antibody to Pim-1 Oncogene (PIM1)

PAC578Ra01 100ul
EUR 266

Polyclonal Antibody to Pim-3 Oncogene (PIM3)

PAN637Hu01 100ul
EUR 270

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat)

4-PAC578Ra01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1)

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse)

4-PAC578Mu01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1)

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human)

4-PAN637Hu01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3)

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), PE

4-PAC578Ra01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), APC

4-PAC578Ra01-APC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), Cy3

4-PAC578Ra01-Cy3
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), HRP

4-PAC578Ra01-HRP
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), PE

4-PAC578Mu01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), FITC

4-PAC578Ra01-FITC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), PE

4-PAN637Hu01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), APC

4-PAC578Mu01-APC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with APC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), Cy3

4-PAC578Mu01-Cy3
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  • 100ul
  • 10ml
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Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), HRP

4-PAC578Mu01-HRP
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  • 100ul
  • 10ml
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Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), APC

4-PAN637Hu01-APC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with APC.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), Cy3

4-PAN637Hu01-Cy3
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with Cy3.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), HRP

4-PAN637Hu01-HRP
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  • 100ul
  • 10ml
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Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with HRP.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), FITC

4-PAC578Mu01-FITC
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  • 100ul
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  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), FITC

4-PAN637Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
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Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with FITC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), APC-Cy7

4-PAC578Ra01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), Biotinylated

4-PAC578Ra01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat)

4-PAC578Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1)

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC578Mu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), APC-Cy7

4-PAN637Hu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), Biotinylated

4-PAC578Mu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), Biotinylated

4-PAN637Hu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with Biotin.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), PE

4-PAC578Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
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Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), APC

4-PAC578Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), Cy3

4-PAC578Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), HRP

4-PAC578Hu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), FITC

4-PAC578Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), APC-Cy7

4-PAC578Hu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), Biotinylated

4-PAC578Hu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.

PIM2 (untagged)-Human pim-2 oncogene (PIM2)

SC115825 10 µg Ask for price

Recombinant Pim-2 Oncogene (PIM2)

RPU51241-100ug 100ug
EUR 468.6

Recombinant Pim-2 Oncogene (PIM2)

RPU51241-1mg 1mg
EUR 2074.8

Recombinant Pim-2 Oncogene (PIM2)

RPU51241-50ug 50ug
EUR 376.2

Recombinant Pim-2 Oncogene (PIM2)

RPU43301-100ug 100ug
EUR 504.9

Recombinant Pim-2 Oncogene (PIM2)

RPU43301-1mg 1mg
EUR 2238.6

Recombinant Pim-2 Oncogene (PIM2)

RPU43301-50ug 50ug
EUR 405.9

Recombinant Pim-2 Oncogene (PIM2)

RPU43302-100ug 100ug
EUR 530.2

Recombinant Pim-2 Oncogene (PIM2)

RPU43302-1mg 1mg
EUR 2347.8

Recombinant Pim-2 Oncogene (PIM2)

RPU43302-50ug 50ug
EUR 425.7

Recombinant Pim-2 Oncogene (PIM2)

RPP797Hu01 10ug
EUR 152

Recombinant Pim-2 Oncogene (PIM2)

4-RPP797Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Pim-2 Oncogene expressed in: E.coli

Recombinant Pim-2 Oncogene (PIM2)

RPP797Mu01 10ug
EUR 164

Recombinant Pim-2 Oncogene (PIM2)

4-RPP797Mu01
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  • 100 ug
  • 10ug
  • 1 mg
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  • 50ug
  • 5 mg
Description: Recombinant Mouse Pim-2 Oncogene expressed in: E.coli

Recombinant Pim-2 Oncogene (PIM2)

RPP797Ra01 10ug
EUR 172

Recombinant Pim-2 Oncogene (PIM2)

4-RPP797Ra01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
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  • 50ug
  • 5 mg
Description: Recombinant Rat Pim-2 Oncogene expressed in: E.coli

PIM2 (GFP-tagged) - Human pim-2 oncogene (PIM2)

RG201933 10 µg Ask for price

Rat Pim-2 Oncogene (PIM2) Protein

20-abx068550
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Pim-2 Oncogene (PIM2) Protein

abx068550-20g 20 µg
EUR 387.5

Rat Pim-2 Oncogene (PIM2) Protein

abx068550-5g 5 µg
EUR 225

Mouse Pim-2 Oncogene (PIM2) Protein

20-abx068549
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Pim-2 Oncogene (PIM2) Protein

20-abx168058
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Pim-2 Oncogene (PIM2) Protein

abx168058-100l 100 µl
EUR 212.5

Human Pim-2 Oncogene (PIM2) Protein

abx168058-1ml 1 ml
EUR 512.5

Human Pim-2 Oncogene (PIM2) Protein

abx168058-200l 200 µl
EUR 362.5

Mouse Pim-2 Oncogene (PIM2) Protein

abx068549-20g 20 µg
EUR 375

Mouse Pim-2 Oncogene (PIM2) Protein

abx068549-5g 5 µg
EUR 212.5

PIM2 (Myc-DDK-tagged)-Human pim-2 oncogene (PIM2)

RC201933 10 µg Ask for price

CLIA Kit for Pim-2 Oncogene (PIM2)

SCP797Hu 96Т
EUR 840

Rat Pim-2 Oncogene(PIM2))ELISA Kit

QY-E10538 96T
EUR 480

ELISA Kit for Pim-2 Oncogene (PIM2)

SEP797Hu 96Т
EUR 770

Human Pim-2 Oncogene (PIM2) CLIA Kit

EKU09423-48T 48T
EUR 666.82

Human Pim-2 Oncogene (PIM2) CLIA Kit

EKU09423-5x96T 5x96T
EUR 4524.85

Human Pim-2 Oncogene (PIM2) CLIA Kit

EKU09423-96T 96T
EUR 952.6

Human Pim-2 Oncogene (PIM2) CLIA Kit

EKN50534-48T 48T
EUR 414.89

Human Pim-2 Oncogene (PIM2) CLIA Kit

EKN50534-5x96T 5x96T
EUR 2815.33

Human Pim-2 Oncogene (PIM2) CLIA Kit

EKN50534-96T 96T
EUR 592.7

Human Pim-2 Oncogene (PIM2) CLIA Kit

20-abx190021
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Pim-2 Oncogene (PIM2)CLIA Kit

SCP797Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2)CLIA Kit

SCP797Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2)CLIA Kit

SCP797Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2)CLIA Kit

SCP797Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) CLIA Kit

4-SCP797Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2)Serum, plasma, tissue homogenates and other biological fluids

Human Pim-2 Oncogene (PIM2) ELISA Kit

201-12-2346 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit

DLR-PIM2-Hu 96T
EUR 505
Description: serum, plasma, tissue homogenates or other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit

DLR-PIM2-Hu-48T 48T
EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Pim-2 Oncogene (PIM2) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit

DLR-PIM2-Hu-96T 96T
EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Pim-2 Oncogene (PIM2) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit

EKN47753-48T 48T
EUR 416.29

Human Pim-2 Oncogene (PIM2) ELISA Kit

EKN47753-5x96T 5x96T
EUR 2824.83

Human Pim-2 Oncogene (PIM2) ELISA Kit

EKN47753-96T 96T
EUR 594.7

Human Pim-2 Oncogene (PIM2) ELISA Kit

EKU06642-48T 48T
EUR 610.82

Human Pim-2 Oncogene (PIM2) ELISA Kit

EKU06642-5x96T 5x96T
EUR 4144.85

Human Pim-2 Oncogene (PIM2) ELISA Kit

EKU06642-96T 96T
EUR 872.6

Human Pim-2 Oncogene (PIM2) ELISA Kit

DL-PIM2-Hu 96T
EUR 481
Description: serum, plasma, tissue homogenates or other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit

EK16104 96Т
EUR 768

Human Pim-2 Oncogene (PIM2) ELISA Kit

20-abx152745
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Pim-2 Oncogene (PIM2) ELISA Kit

RD-PIM2-Hu-48T 48T
EUR 493.5
Description: serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit

RD-PIM2-Hu-48Tests 48 Tests
EUR 675.6

Human Pim-2 Oncogene (PIM2) ELISA Kit

RD-PIM2-Hu-96T 96T
EUR 705
Description: serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit

RD-PIM2-Hu-96Tests 96 Tests
EUR 939.6

Mouse Pim-2 Oncogene(PIM2))ELISA Kit

QY-E21185 96T
EUR 433.2

Human Pim-2 Oncogene(PIM2)ELISA Kit

QY-E04697 96T
EUR 433.2

Human Pim-2 Oncogene (PIM2) ELISA Kit

SEP797Hu-10x96wellstestplate 10x96-wells test plate
EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit

SEP797Hu-1x48wellstestplate 1x48-wells test plate
EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit

SEP797Hu-1x96wellstestplate 1x96-wells test plate
EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Snelle oppervlakte-immobilisatie van natieve  eiwitten  door katalysatorvrije amino-yn-klik-bioconjugatie

Oppervlakte-immobilisatie biedt een nuttig platform voor biosensing, screening van geneesmiddelen, weefselengineering en andere chemische en biologische toepassingen. Echter , sommige van de gebruikte reacties zijn inefficiënt en / of ingewikkeld, hun toepassingen te beperken in immobilisatie. Hierin gebruiken we een spontane en katalysatorvrije amino-yn-klik bioconjugatie om geactiveerde met ethynylgroep gefunctionaliseerde oppervlakken te genereren voor snelle immobilisatie van inheemse eiwitten en cellen.

Biomoleculen, zoals runderserumalbumine (BSA) , humaan IgG en een peptide van C(RGDfK), konden in slechts 30 minuten covalent op de oppervlakken worden geïmmobiliseerd. Met identify de biologische activiteit van de verankerde biomoleculen blijft intact, wat wordt geverifieerd door het efficiënt vastleggen van doelantilichamen en cellen uit de bulkoplossingen. Deze strategie vertegenwoordigt een alternatief voor zeer efficiënte biofunctionalisatie van het oppervlak.

Over de bindingsreactie van loratadine met humaan serum acute fase-  eiwit  alfa-1-zuur glyco- eiwit

Loratadine is een belangrijk anti-allergisch medicijn. Het is een antihistaminicum van de tweede generatie dat wordt gebruikt voor de behandeling van allergische rhinitis, hooikoorts en urticaria. Humaan alfa-1-zuur-glycoproteïne (AG) in serum is een belangrijk eiwit in de acute fase en de serumconcentratie ervan blijkt te stijgen bij ontsteking en acute respons. De bindingsinteractie tussen loratadine en AG wordt bestudeerd met behulp van spectroscopie en moleculaire koppeltechnieken. De resultaten verkregen uit fluorescentie- uitdovingsexperimenten toonden aan dat de fluorescentie-intensiteit van AG wordt gedoofd door loratadine. Loratadine bleek AG binden aan de bindingsconstante van ≈10 4  bij 298 Okay.

De vrije energieverandering van Gibb bleek negatief te zijn voor de interactie van loratadine met AG, wat aangeeft dat het bindingsproces spontaan is. Binding van loratadine met AG induceerde geordende structuren in het eiwit. Waterstofbinding en hydrofobe interacties waren de belangrijkste bindingskrachten tussen AG-loratadine, zoals blijkt uit moleculaire koppelingsresultaten. Deze studie suggereert het belang van het ruimtelijk binden van anti-allergische geneesmiddelen aan AG bij ziekten waarbij de plasmaconcentratie van AG vele malen toeneemt en interactie met dit eiwit vital wordt. Deze studie zal helpen bij het ontwerpen van de medicijndosering en dienovereenkomstige aanpassing om een ​​optimaal behandelresultaat te bereiken. Gecommuniceerd door Ramaswamy H. Sarma.

Gerichte  Protein  Degradatie door middel van Quick optogenetische Activering en de toepassing ervan op de beheersing van de Cell Signaling

De ontwikkeling van methodologieën voor optisch getriggerde eiwitafbraak maakt de studie mogelijk van dynamische eiwitfuncties, zoals die welke betrokken zijn bij celsignalering , die moeilijk te onderzoeken zijn met traditionele genetische technieken. Hier beschrijven we het ontwerp en de implementatie van een nieuw lichtgecontroleerd peptide-degron dat N-end-pathway-degradatie aan zijn eiwitdoelwit verleent. De degron omvat een fotogekooid N-terminaal aminozuur en een lysinerijke linker met 13 residu’s. Door het N-terminale residu te kooien , waren we in staat om de herkenning van N-degron door een E3-ligase optisch te regelen, waardoor de ubiquitinatie en proteasomale afbraak van het doeleiwit werd gecontroleerd.

We demonstreren brede toepasbaarheid door deze benadering toe te passen op een various reeks doeleiwitten, waaronder EGFP, vuurvliegluciferase, de kinase MEK1 en de fosfatase DUSP6 (ook bekend als MKP3). De gekooide degron kan worden gebruikt met minimale eiwittechnologie en biedt vrijwel volledige, door licht geactiveerde eiwitafbraak op een tijdschaal van seconden tot minuut.

 

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