Snel opkomende SARS-CoV-2 B.1.1.7 sub-lijn in de Verenigde Staten van Amerika met spike  eiwit  D178H en membraan  eiwit  V70L mutaties

 

Samenvatting De SARS-CoV-2 B.1.1.7-afstamming is zeer besmettelijk en was vanaf april 2021 goed voor 92% van de COVID-19-gevallen in Europa en 59% van de COVID-19-gevallen in de VS. Het wordt gedefinieerd door de N501Y-mutatie in het receptorbindende domein (RBD) van het Spike (S)-eiwit en enkele andere mutaties. Deze omvatten twee mutaties in het N-terminale domein (NTD)van het S-eiwit, HV69-70del en Y144del (ook bekend als Y145del vanwege de aanwezigheid van tyrosine op beide posities). We hebben onlangs verschillende opkomende SARS-CoV-2-varianten van problemen geïdentificeerd, gekenmerkt door membraan (M) -eiwitmutaties, waaronder I82T en V70L. We identificeren nu een sublijn van B.1.1.7 die ontstond door opeenvolgende acquisities van M:V70L in november 2020, gevolgd door een nieuwe S:D178H-mutatie die voor het eerst werd waargenomen start februari 2021.

 

Het proportion B.1.1.7-isolaten in de VS dat tot deze sublijn behoort, is gestegen van 0,15% in februari 2021 tot 1,8% in april 2021. Tot op heden lijkt deze sublijn specifiek voor de VS te zijn met gemelde gevallen in 31 staten, waaronder Hawaï. Vanaf april 2021 vormde het 36,8% van alle B.1.1.7-isolaten in Washington. Fylogenetische analyse en transmissie-inferentie met Nextstrain suggereert dat deze sublijn waarschijnlijk afkomstig is uit Californië of Washington . Structurele analyse onthulde dat de S:D178H-mutatie zich in de NTD van het S-eiwit bevindt en dicht bij twee andere kenmerkende mutaties van B.1.1.7, HV69-70del en Y144del. Het is aan het oppervlak blootgesteld en kan de tertiaire configuratie of toegankelijkheid van NTD veranderen, en heeft dus het potentieel om neutralisatie door NTD-gerichte antilichamen te beïnvloeden.

 

Snelle driedimensionale vormbepaling van bolvormige  eiwitten  door capillaire elektroforese van mobiliteit en natieve massaspectrometrie

Gevestigde proteomics-methoden met hoge doorvoer bieden beperkte informatie over de stereostructuren van eiwitten. Traditionele technologieën voor het bepalen van de eiwitstructuur vereisen doorgaans moeizame stappen en kunnen niet op een high-throughput-manier worden uitgevoerd. Hier rapporteren we een nieuwe medium throughput-methode door mobiliteit capillaire elektroforese (MCE) en native massaspectrometrie (MS) te combineren voor de 3-dimensionale (3D) vormbepaling van bolvormige eiwitten in de vloeibare fase , die zowel de geometrische structuur als de moleculaire massa-informatie van eiwitten.

Er werd een theorie ontwikkeld om de hydrodynamische straal van ionen en de verdeling van de ladingstoestand in het natieve massaspectrum te correleren met geometrische eiwitparameters, waardoor een lage-resolutiestructuur (vorm) van het eiwit kon worden bepaald. Onze testgegevens van 11 verschillende globulaire eiwitten toonden aan dat deze benadering ons in staat stelt om de vormen van individuele eiwitten, eiwitcomplexen en eiwitten in een mengsel te bepalen en om veranderingen in eiwitconformatie te volgen. Naast het verstrekken van aanvullende informatie over de eiwitstructuur en het vermogen om mengsels te analyseren, is deze op MCE en native MS gebaseerde methode snel in snelheid en laag in monsterconsumptie, waardoor deze mogelijk toepasbaar is in top-down proteomics en structurele biologie voor intacte globulaire eiwit- of eiwitcomplexanalyse.

Human Pim-2 Oncogene (PIM2) ELISA Kit
RD-PIM2-Hu-48Tests	Reddot Biotech	48 Tests	EUR 563

Human Pim-2 Oncogene (PIM2) ELISA Kit
RD-PIM2-Hu-96Tests	Reddot Biotech	96 Tests	EUR 783

Human Pim-2 Oncogene (PIM2) ELISA Kit
RDR-PIM2-Hu-48Tests	Reddot Biotech	48 Tests	EUR 589

Human Pim-2 Oncogene (PIM2) ELISA Kit
RDR-PIM2-Hu-96Tests	Reddot Biotech	96 Tests	EUR 820

Pim-2 Oncogene (PIM2) Antibody
20-abx129066	Abbexa	EUR 453.00 EUR 133.00 EUR 1316.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-2 Oncogene (PIM2) Antibody
abx431508-200ul	Abbexa	200 ul	EUR 384

Pim-2 Oncogene (PIM2) Antibody
abx433133-200ul	Abbexa	200 ul	EUR 384

Pim-2 Oncogene (PIM2) Antibody
abx433134-200ul	Abbexa	200 ul	EUR 384

Pim-2 Oncogene (PIM2) Antibody
abx236456-100ug	Abbexa	100 ug	EUR 551

Pim-2 Oncogene (PIM2) Antibody
20-abx174067	Abbexa	EUR 926.00 EUR 467.00	1 mg 200 ug

Pim-2 Oncogene (PIM2) Antibody
20-abx101236	Abbexa	EUR 467.00 EUR 133.00 EUR 1344.00 EUR 634.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-2 Oncogene (PIM2) Antibody
20-abx101237	Abbexa	EUR 481.00 EUR 133.00 EUR 1414.00 EUR 662.00 EUR 356.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human)
4-PAP797Hu01	Cloud-Clone	EUR 262.00 EUR 2747.00 EUR 679.00 EUR 331.00 EUR 220.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2)

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse)
4-PAP797Mu01	Cloud-Clone	EUR 266.00 EUR 2813.00 EUR 694.00 EUR 337.00 EUR 222.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2)

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat)
4-PAP797Ra01	Cloud-Clone	EUR 275.00 EUR 2958.00 EUR 727.00 EUR 350.00 EUR 226.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2)

Recombinant Pim-2 Oncogene (PIM2)
4-RPP797Hu01	Cloud-Clone	EUR 440.48 EUR 221.00 EUR 1376.80 EUR 525.60 EUR 951.20 EUR 358.00 EUR 3292.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Pim-2 Oncogene expressed in: E.coli

Recombinant Pim-2 Oncogene (PIM2)
4-RPP797Mu01	Cloud-Clone	EUR 467.36 EUR 228.00 EUR 1477.60 EUR 559.20 EUR 1018.40 EUR 376.00 EUR 3544.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Pim-2 Oncogene expressed in: E.coli

Recombinant Pim-2 Oncogene (PIM2)
4-RPP797Ra01	Cloud-Clone	EUR 485.28 EUR 233.00 EUR 1544.80 EUR 581.60 EUR 1063.20 EUR 388.00 EUR 3712.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Pim-2 Oncogene expressed in: E.coli

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), APC
4-PAP797Hu01-APC	Cloud-Clone	EUR 368.00 EUR 3599.00 EUR 993.00 EUR 472.00 EUR 229.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with APC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), Biotinylated
4-PAP797Hu01-Biotin	Cloud-Clone	EUR 328.00 EUR 2697.00 EUR 786.00 EUR 404.00 EUR 226.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with Biotin.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), Cy3
4-PAP797Hu01-Cy3	Cloud-Clone	EUR 449.00 EUR 4757.00 EUR 1283.00 EUR 588.00 EUR 264.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with Cy3.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), FITC
4-PAP797Hu01-FITC	Cloud-Clone	EUR 314.00 EUR 2899.00 EUR 814.00 EUR 397.00 EUR 203.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with FITC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), HRP
4-PAP797Hu01-HRP	Cloud-Clone	EUR 335.00 EUR 3135.00 EUR 877.00 EUR 426.00 EUR 215.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with HRP.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), PE
4-PAP797Hu01-PE	Cloud-Clone	EUR 314.00 EUR 2899.00 EUR 814.00 EUR 397.00 EUR 203.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with PE.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), APC
4-PAP797Mu01-APC	Cloud-Clone	EUR 374.00 EUR 3689.00 EUR 1016.00 EUR 481.00 EUR 232.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with APC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), Biotinylated
4-PAP797Mu01-Biotin	Cloud-Clone	EUR 332.00 EUR 2763.00 EUR 803.00 EUR 411.00 EUR 228.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with Biotin.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), Cy3
4-PAP797Mu01-Cy3	Cloud-Clone	EUR 457.00 EUR 4877.00 EUR 1313.00 EUR 600.00 EUR 267.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with Cy3.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), FITC
4-PAP797Mu01-FITC	Cloud-Clone	EUR 319.00 EUR 2971.00 EUR 832.00 EUR 405.00 EUR 205.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with FITC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), HRP
4-PAP797Mu01-HRP	Cloud-Clone	EUR 341.00 EUR 3213.00 EUR 897.00 EUR 433.00 EUR 217.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with HRP.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), PE
4-PAP797Mu01-PE	Cloud-Clone	EUR 319.00 EUR 2971.00 EUR 832.00 EUR 405.00 EUR 205.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with PE.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), APC
4-PAP797Ra01-APC	Cloud-Clone	EUR 388.00 EUR 3887.00 EUR 1065.00 EUR 501.00 EUR 237.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with APC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), Biotinylated
4-PAP797Ra01-Biotin	Cloud-Clone	EUR 343.00 EUR 2908.00 EUR 839.00 EUR 425.00 EUR 232.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with Biotin.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), Cy3
4-PAP797Ra01-Cy3	Cloud-Clone	EUR 476.00 EUR 5141.00 EUR 1379.00 EUR 626.00 EUR 275.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with Cy3.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), FITC
4-PAP797Ra01-FITC	Cloud-Clone	EUR 330.00 EUR 3129.00 EUR 872.00 EUR 420.00 EUR 210.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with FITC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), HRP
4-PAP797Ra01-HRP	Cloud-Clone	EUR 353.00 EUR 3385.00 EUR 940.00 EUR 451.00 EUR 222.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with HRP.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), PE
4-PAP797Ra01-PE	Cloud-Clone	EUR 330.00 EUR 3129.00 EUR 872.00 EUR 420.00 EUR 210.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with PE.

Human Pim-2 Oncogene (PIM2) Protein
20-abx168058	Abbexa	EUR 620.00 EUR 272.00 EUR 1859.00 EUR 732.00 EUR 453.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Pim-2 Oncogene (PIM2) Protein
20-abx068549	Abbexa	EUR 648.00 EUR 272.00 EUR 1998.00 EUR 773.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug

Rat Pim-2 Oncogene (PIM2) Protein
20-abx068550	Abbexa	EUR 676.00 EUR 286.00 EUR 2082.00 EUR 801.00 EUR 481.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), APC-Cy7
4-PAP797Hu01-APC-Cy7	Cloud-Clone	EUR 616.00 EUR 7078.00 EUR 1867.00 EUR 824.00 EUR 338.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with APC-Cy7.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), APC-Cy7
4-PAP797Mu01-APC-Cy7	Cloud-Clone	EUR 628.00 EUR 7258.00 EUR 1912.00 EUR 842.00 EUR 344.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with APC-Cy7.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), APC-Cy7
4-PAP797Ra01-APC-Cy7	Cloud-Clone	EUR 657.00 EUR 7654.00 EUR 2011.00 EUR 882.00 EUR 355.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with APC-Cy7.

Human Pim-2 Oncogene (PIM2)CLIA Kit
SCP797Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5647.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2)CLIA Kit
SCP797Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 552.76
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2)CLIA Kit
SCP797Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 746.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2)CLIA Kit
SCP797Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3060.6
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) CLIA Kit
4-SCP797Hu	Cloud-Clone	EUR 5698.00 EUR 3061.00 EUR 747.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2)Serum, plasma, tissue homogenates and other biological fluids

Human Pim-2 Oncogene (PIM2) ELISA Kit
SEP797Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5189.65
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
SEP797Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 515.03
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
SEP797Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 692.9
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
SEP797Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2818.05
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
4-SEP797Hu	Cloud-Clone	EUR 5240.00 EUR 2769.00 EUR 693.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Pim-2 Oncogene (PIM2) in samples from Serum, plasma, tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Pim-2 Oncogene (PIM2) ELISA Kit
201-12-2346	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Pim-2 Oncogene (PIM2) CLIA Kit
20-abx190021	Abbexa	EUR 7911.00 EUR 4215.00 EUR 973.00	10 × 96 tests 5 × 96 tests 96 tests

Human Pim-2 Oncogene (PIM2) ELISA Kit
20-abx152745	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Rat Pim-2 Oncogene(PIM2))ELISA Kit
QY-E10538	Qayee Biotechnology	96T	EUR 400

Mouse Pim-2 Oncogene(PIM2))ELISA Kit
QY-E21185	Qayee Biotechnology	96T	EUR 361

Human Pim-2 Oncogene(PIM2)ELISA Kit
QY-E04697	Qayee Biotechnology	96T	EUR 361

ELISA kit for Human PIM2 (Pim-2 Oncogene)
ELK6492	ELK Biotech	1 plate of 96 wells	EUR 432
Description: A sandwich ELISA kit for detection of Pim-2 Oncogene from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 349

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Antibody
20-abx322889	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Antibody
20-abx212237	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Antibody
20-abx212644	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Antibody
20-abx302167	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Antibody
abx033773-400ul	Abbexa	400 ul	EUR 523

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Antibody
abx033773-80l	Abbexa	80 µl	EUR 286

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 280

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Antibody (HRP)
20-abx314668	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Antibody (FITC)
20-abx314669	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Antibody (Biotin)
20-abx314670	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Rabbit Pim 1 Oncogene ELISA kit
E04P0753-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Pim 1 Oncogene ELISA kit
E04P0753-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Pim 1 Oncogene ELISA kit
E04P0753-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Serine/Threonine-Protein Kinase Pim-2 (PIM2) Protein
20-abx262771	Abbexa	EUR 328.00 EUR 6397.00 EUR 230.00	10 ug 1 mg 2 µg

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human)
4-PAN637Hu01	Cloud-Clone	EUR 262.00 EUR 2747.00 EUR 679.00 EUR 331.00 EUR 220.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3)

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse)
4-PAC578Mu01	Cloud-Clone	EUR 251.00 EUR 2576.00 EUR 640.00 EUR 316.00 EUR 215.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1)

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat)
4-PAC578Ra01	Cloud-Clone	EUR 259.00 EUR 2708.00 EUR 670.00 EUR 328.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1)

Anti-Pim-2 antibody
STJ95094	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Pim-2.

Pim-1 Oncogene (PIM1) Antibody
20-abx174066	Abbexa	EUR 857.00 EUR 439.00	1 mg 200 ug

Pim-3 Oncogene (PIM3) Antibody
20-abx174068	Abbexa	EUR 926.00 EUR 467.00	1 mg 200 ug

Pim-1 Oncogene (PIM1) Antibody
20-abx101233	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-1 Oncogene (PIM1) Antibody
20-abx101234	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-1 Oncogene (PIM1) Antibody
20-abx101235	Abbexa	EUR 453.00 EUR 133.00 EUR 1302.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-3 Oncogene (PIM3) Antibody
20-abx131576	Abbexa	EUR 453.00 EUR 133.00 EUR 1316.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-1 Oncogene (PIM1) Antibody
abx146417-100ug	Abbexa	100 ug	EUR 391

Pim-2 Polyclonal Antibody
ABP53587-003ml	Abbkine	0.03ml	EUR 158
Description: A polyclonal antibody for detection of Pim-2 from Human. This Pim-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Pim-2

Pim-2 Polyclonal Antibody
ABP53587-01ml	Abbkine	0.1ml	EUR 289
Description: A polyclonal antibody for detection of Pim-2 from Human. This Pim-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Pim-2

Pim-2 Polyclonal Antibody
ABP53587-02ml	Abbkine	0.2ml	EUR 414
Description: A polyclonal antibody for detection of Pim-2 from Human. This Pim-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Pim-2

Pim-2 Polyclonal Antibody
ES4586-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against Pim-2 from Human. This antibody is tested and validated for IHC, WB, ELISA

Pim-2 Polyclonal Antibody
ES4586-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against Pim-2 from Human. This antibody is tested and validated for IHC, WB, ELISA

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), APC
4-PAN637Hu01-APC	Cloud-Clone	EUR 368.00 EUR 3599.00 EUR 993.00 EUR 472.00 EUR 229.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with APC.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), Biotinylated
4-PAN637Hu01-Biotin	Cloud-Clone	EUR 328.00 EUR 2697.00 EUR 786.00 EUR 404.00 EUR 226.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with Biotin.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), Cy3
4-PAN637Hu01-Cy3	Cloud-Clone	EUR 449.00 EUR 4757.00 EUR 1283.00 EUR 588.00 EUR 264.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with Cy3.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), FITC
4-PAN637Hu01-FITC	Cloud-Clone	EUR 314.00 EUR 2899.00 EUR 814.00 EUR 397.00 EUR 203.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with FITC.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), HRP
4-PAN637Hu01-HRP	Cloud-Clone	EUR 335.00 EUR 3135.00 EUR 877.00 EUR 426.00 EUR 215.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with HRP.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), PE
4-PAN637Hu01-PE	Cloud-Clone	EUR 314.00 EUR 2899.00 EUR 814.00 EUR 397.00 EUR 203.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), APC
4-PAC578Mu01-APC	Cloud-Clone	EUR 351.00 EUR 3365.00 EUR 935.00 EUR 449.00 EUR 222.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with APC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), Biotinylated
4-PAC578Mu01-Biotin	Cloud-Clone	EUR 316.00 EUR 2526.00 EUR 744.00 EUR 387.00 EUR 221.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), Cy3
4-PAC578Mu01-Cy3	Cloud-Clone	EUR 427.00 EUR 4445.00 EUR 1205.00 EUR 557.00 EUR 254.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), FITC
4-PAC578Mu01-FITC	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), HRP
4-PAC578Mu01-HRP	Cloud-Clone	EUR 321.00 EUR 2933.00 EUR 827.00 EUR 405.00 EUR 209.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), PE
4-PAC578Mu01-PE	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), APC
4-PAC578Ra01-APC	Cloud-Clone	EUR 364.00 EUR 3545.00 EUR 980.00 EUR 467.00 EUR 227.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), Biotinylated
4-PAC578Ra01-Biotin	Cloud-Clone	EUR 325.00 EUR 2658.00 EUR 777.00 EUR 400.00 EUR 225.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), Cy3
4-PAC578Ra01-Cy3	Cloud-Clone	EUR 444.00 EUR 4685.00 EUR 1265.00 EUR 581.00 EUR 261.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), FITC
4-PAC578Ra01-FITC	Cloud-Clone	EUR 311.00 EUR 2856.00 EUR 804.00 EUR 393.00 EUR 202.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), HRP
4-PAC578Ra01-HRP	Cloud-Clone	EUR 332.00 EUR 3089.00 EUR 866.00 EUR 421.00 EUR 213.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), PE
4-PAC578Ra01-PE	Cloud-Clone	EUR 311.00 EUR 2856.00 EUR 804.00 EUR 393.00 EUR 202.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with PE.

Anti-PIM2 antibody
PAab06456	Lifescience Market	100 ug	EUR 412

Anti-PIM2 antibody
STJ118061	St John's Laboratory	100 µl	EUR 277

Anti-PIM2 antibody
STJ72541	St John's Laboratory	100 µg	EUR 359

anti- PIM2 antibody
FNab06456	FN Test	100µg	EUR 585
Description: Antibody raised against PIM2

anti-PIM2
YF-PA17388	Abfrontier	50 ul	EUR 363
Description: Mouse polyclonal to Anti-PIM2

anti-PIM2
YF-PA17389	Abfrontier	50 ug	EUR 363
Description: Mouse polyclonal to Anti-PIM2

anti-PIM2
YF-PA17390	Abfrontier	100 ul	EUR 403
Description: Rabbit polyclonal to Anti-PIM2

anti-PIM2
YF-PA17391	Abfrontier	100 ug	EUR 403
Description: Rabbit polyclonal to Anti-PIM2

Pim-1 Oncogene (PIM1) Antibody (Biotin)
20-abx271779	Abbexa	EUR 453.00 EUR 244.00 EUR 1316.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-1 Oncogene (PIM1) Antibody (Biotin)
20-abx272590	Abbexa	EUR 467.00 EUR 244.00 EUR 1344.00 EUR 634.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-1 Oncogene (PIM1) Antibody (Biotin)
20-abx273089	Abbexa	EUR 481.00 EUR 244.00 EUR 1414.00 EUR 662.00 EUR 356.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Serine/threonine- protein kinase pim- 2, Pim2 ELISA KIT
ELI-43622m	Lifescience Market	96 Tests	EUR 865

Human Serine/threonine- protein kinase pim- 2, PIM2 ELISA KIT
ELI-36413h	Lifescience Market	96 Tests	EUR 824

Human Serine/threonine-protein kinase pim-2 (PIM2) ELISA Kit
abx573365-96tests	Abbexa	96 tests	EUR 668

Mouse Serine/threonine-protein kinase pim-2 (PIM2) ELISA Kit
abx555894-96tests	Abbexa	96 tests	EUR 668

Mouse Pim2/ Serine/threonine-protein kinase pim-2 ELISA Kit
E1139Mo	Sunlong	1 Kit	EUR 571

Human PIM2(Serine/threonine-protein kinase pim-2) ELISA Kit
EH11135	FN Test	96T	EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Recombinant Pim-3 Oncogene (PIM3)
4-RPN637Hu01	Cloud-Clone	EUR 467.36 EUR 228.00 EUR 1477.60 EUR 559.20 EUR 1018.40 EUR 376.00 EUR 3544.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Pim-3 Oncogene expressed in: E.coli

Recombinant Pim-1 Oncogene (PIM1)
4-RPC578Hu01	Cloud-Clone	EUR 467.36 EUR 228.00 EUR 1477.60 EUR 559.20 EUR 1018.40 EUR 376.00 EUR 3544.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Pim-1 Oncogene expressed in: E.coli

Recombinant Pim-1 Oncogene (PIM1)
4-RPC578Mu01	Cloud-Clone	EUR 476.32 EUR 230.00 EUR 1511.20 EUR 570.40 EUR 1040.80 EUR 382.00 EUR 3628.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Pim-1 Oncogene expressed in: E.coli

Recombinant Pim-1 Oncogene (PIM1)
4-RPC578Ra01	Cloud-Clone	EUR 467.36 EUR 228.00 EUR 1477.60 EUR 559.20 EUR 1018.40 EUR 376.00 EUR 3544.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Pim-1 Oncogene expressed in: E.coli

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), APC-Cy7
4-PAN637Hu01-APC-Cy7	Cloud-Clone	EUR 616.00 EUR 7078.00 EUR 1867.00 EUR 824.00 EUR 338.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat)
4-PAC578Hu01	Cloud-Clone	EUR 247.00 EUR 2510.00 EUR 625.00 EUR 310.00 EUR 214.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1)

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), APC-Cy7
4-PAC578Mu01-APC-Cy7	Cloud-Clone	EUR 583.00 EUR 6610.00 EUR 1750.00 EUR 778.00 EUR 324.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), APC-Cy7
4-PAC578Ra01-APC-Cy7	Cloud-Clone	EUR 608.00 EUR 6970.00 EUR 1840.00 EUR 814.00 EUR 335.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.

Anti-Bcl-2 Rabbit Monoclonal Antibody
M00040-2	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Bcl-2 Antibody. Validated in IF, WB and tested in Human, Mouse.

PIM2 Rabbit pAb
A15598-100ul	Abclonal	100 ul	EUR 308

PIM2 Rabbit pAb
A15598-200ul	Abclonal	200 ul	EUR 459

PIM2 Rabbit pAb
A15598-20ul	Abclonal	20 ul	EUR 183

PIM2 Rabbit pAb
A15598-50ul	Abclonal	50 ul	EUR 223

ELISA kit for Mouse Serine/threonine-protein kinase pim-2 (PIM2)
KTE70749-48T	Abbkine	48T	EUR 332
Description: Quantitative sandwich ELISA for measuring Mouse Serine/threonine-protein kinase pim-2 (PIM2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Serine/threonine-protein kinase pim-2 (PIM2)
KTE70749-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115
Description: Quantitative sandwich ELISA for measuring Mouse Serine/threonine-protein kinase pim-2 (PIM2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Serine/threonine-protein kinase pim-2 (PIM2)
KTE70749-96T	Abbkine	96T	EUR 539
Description: Quantitative sandwich ELISA for measuring Mouse Serine/threonine-protein kinase pim-2 (PIM2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Anti-PIM2 (Internal) antibody
STJ70829	St John's Laboratory	100 µg	EUR 359

Mouse Pim 1 Oncogene ELISA kit
E03P0753-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Pim 1 Oncogene ELISA kit
E03P0753-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Pim 1 Oncogene ELISA kit
E03P0753-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Pim 1 Oncogene ELISA kit
E02P0753-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Pim 1 Oncogene ELISA kit
E02P0753-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Pim 1 Oncogene ELISA kit
E02P0753-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Pim 1 Oncogene ELISA kit
E01P0753-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Pim 1 Oncogene ELISA kit
E01P0753-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Human Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Pim 1 Oncogene ELISA kit
E01P0753-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Pim 1 Oncogene ELISA kit
E08P0753-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Pim 1 Oncogene ELISA kit
E08P0753-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Canine Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Pim 1 Oncogene ELISA kit
E08P0753-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Pim 1 Oncogene ELISA kit
E06P0753-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Pim 1 Oncogene ELISA kit
E06P0753-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Pim 1 Oncogene ELISA kit
E06P0753-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Pim 1 Oncogene ELISA kit
E07P0753-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Pim 1 Oncogene ELISA kit
E07P0753-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Pim 1 Oncogene ELISA kit
E07P0753-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Pim 1 Oncogene ELISA kit
E09P0753-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Pim 1 Oncogene ELISA kit
E09P0753-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Pim 1 Oncogene ELISA kit
E09P0753-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Pim-3 Oncogene (PIM3) Protein
20-abx650812	Abbexa	EUR 648.00 EUR 272.00 EUR 1998.00 EUR 773.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Pim-1 Oncogene (PIM1) Protein
20-abx068546	Abbexa	EUR 648.00 EUR 272.00 EUR 1998.00 EUR 773.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug

Snelle oppervlakte-immobilisatie van natieve  eiwitten  door katalysatorvrije amino-yn-klik-bioconjugatie

Oppervlakte-immobilisatie biedt een nuttig platform voor biosensing, screening van geneesmiddelen, weefselengineering en andere chemische en biologische toepassingen. Echter , sommige van de gebruikte reacties zijn inefficiënt en / of ingewikkeld, hun toepassingen te beperken in immobilisatie. Hierin gebruiken we een spontane en katalysatorvrije amino-yn-klik bioconjugatie om geactiveerde met ethynylgroep gefunctionaliseerde oppervlakken te genereren voor snelle immobilisatie van inheemse eiwitten en cellen.

Biomoleculen, zoals runderserumalbumine (BSA) , humaan IgG en een peptide van C(RGDfK), konden in slechts 30 minuten covalent op de oppervlakken worden geïmmobiliseerd. Met identify de biologische activiteit van de verankerde biomoleculen blijft intact, wat wordt geverifieerd door het efficiënt vastleggen van doelantilichamen en cellen uit de bulkoplossingen. Deze strategie vertegenwoordigt een alternatief voor zeer efficiënte biofunctionalisatie van het oppervlak.

Over de bindingsreactie van loratadine met humaan serum acute fase-  eiwit  alfa-1-zuur glyco- eiwit

Loratadine is een belangrijk anti-allergisch medicijn. Het is een antihistaminicum van de tweede generatie dat wordt gebruikt voor de behandeling van allergische rhinitis, hooikoorts en urticaria. Humaan alfa-1-zuur-glycoproteïne (AG) in serum is een belangrijk eiwit in de acute fase en de serumconcentratie ervan blijkt te stijgen bij ontsteking en acute respons. De bindingsinteractie tussen loratadine en AG wordt bestudeerd met behulp van spectroscopie en moleculaire koppeltechnieken. De resultaten verkregen uit fluorescentie- uitdovingsexperimenten toonden aan dat de fluorescentie-intensiteit van AG wordt gedoofd door loratadine. Loratadine bleek AG binden aan de bindingsconstante van ≈10 ⁴  bij 298 Okay.

De vrije energieverandering van Gibb bleek negatief te zijn voor de interactie van loratadine met AG, wat aangeeft dat het bindingsproces spontaan is. Binding van loratadine met AG induceerde geordende structuren in het eiwit. Waterstofbinding en hydrofobe interacties waren de belangrijkste bindingskrachten tussen AG-loratadine, zoals blijkt uit moleculaire koppelingsresultaten. Deze studie suggereert het belang van het ruimtelijk binden van anti-allergische geneesmiddelen aan AG bij ziekten waarbij de plasmaconcentratie van AG vele malen toeneemt en interactie met dit eiwit vital wordt. Deze studie zal helpen bij het ontwerpen van de medicijndosering en dienovereenkomstige aanpassing om een ​​optimaal behandelresultaat te bereiken. Gecommuniceerd door Ramaswamy H. Sarma.

Gerichte  Protein  Degradatie door middel van Quick optogenetische Activering en de toepassing ervan op de beheersing van de Cell Signaling

De ontwikkeling van methodologieën voor optisch getriggerde eiwitafbraak maakt de studie mogelijk van dynamische eiwitfuncties, zoals die welke betrokken zijn bij celsignalering , die moeilijk te onderzoeken zijn met traditionele genetische technieken. Hier beschrijven we het ontwerp en de implementatie van een nieuw lichtgecontroleerd peptide-degron dat N-end-pathway-degradatie aan zijn eiwitdoelwit verleent. De degron omvat een fotogekooid N-terminaal aminozuur en een lysinerijke linker met 13 residu’s. Door het N-terminale residu te kooien , waren we in staat om de herkenning van N-degron door een E3-ligase optisch te regelen, waardoor de ubiquitinatie en proteasomale afbraak van het doeleiwit werd gecontroleerd.

We demonstreren brede toepasbaarheid door deze benadering toe te passen op een various reeks doeleiwitten, waaronder EGFP, vuurvliegluciferase, de kinase MEK1 en de fosfatase DUSP6 (ook bekend als MKP3). De gekooide degron kan worden gebruikt met minimale eiwittechnologie en biedt vrijwel volledige, door licht geactiveerde eiwitafbraak op een tijdschaal van seconden tot minuut.