Snel opkomende SARS-CoV-2 B.1.1.7 sub-lijn in de Verenigde Staten van Amerika met spike  eiwit  D178H en membraan  eiwit  V70L mutaties

 

Samenvatting De SARS-CoV-2 B.1.1.7-afstamming is zeer besmettelijk en was vanaf april 2021 goed voor 92% van de COVID-19-gevallen in Europa en 59% van de COVID-19-gevallen in de VS. Het wordt gedefinieerd door de N501Y-mutatie in het receptorbindende domein (RBD) van het Spike (S)-eiwit en enkele andere mutaties. Deze omvatten twee mutaties in het N-terminale domein (NTD)van het S-eiwit, HV69-70del en Y144del (ook bekend als Y145del vanwege de aanwezigheid van tyrosine op beide posities). We hebben onlangs verschillende opkomende SARS-CoV-2-varianten van problemen geïdentificeerd, gekenmerkt door membraan (M) -eiwitmutaties, waaronder I82T en V70L. We identificeren nu een sublijn van B.1.1.7 die ontstond door opeenvolgende acquisities van M:V70L in november 2020, gevolgd door een nieuwe S:D178H-mutatie die voor het eerst werd waargenomen start februari 2021.

 

Het proportion B.1.1.7-isolaten in de VS dat tot deze sublijn behoort, is gestegen van 0,15% in februari 2021 tot 1,8% in april 2021. Tot op heden lijkt deze sublijn specifiek voor de VS te zijn met gemelde gevallen in 31 staten, waaronder Hawaï. Vanaf april 2021 vormde het 36,8% van alle B.1.1.7-isolaten in Washington. Fylogenetische analyse en transmissie-inferentie met Nextstrain suggereert dat deze sublijn waarschijnlijk afkomstig is uit Californië of Washington . Structurele analyse onthulde dat de S:D178H-mutatie zich in de NTD van het S-eiwit bevindt en dicht bij twee andere kenmerkende mutaties van B.1.1.7, HV69-70del en Y144del. Het is aan het oppervlak blootgesteld en kan de tertiaire configuratie of toegankelijkheid van NTD veranderen, en heeft dus het potentieel om neutralisatie door NTD-gerichte antilichamen te beïnvloeden.

 

Snelle driedimensionale vormbepaling van bolvormige  eiwitten  door capillaire elektroforese van mobiliteit en natieve massaspectrometrie

Gevestigde proteomics-methoden met hoge doorvoer bieden beperkte informatie over de stereostructuren van eiwitten. Traditionele technologieën voor het bepalen van de eiwitstructuur vereisen doorgaans moeizame stappen en kunnen niet op een high-throughput-manier worden uitgevoerd. Hier rapporteren we een nieuwe medium throughput-methode door mobiliteit capillaire elektroforese (MCE) en native massaspectrometrie (MS) te combineren voor de 3-dimensionale (3D) vormbepaling van bolvormige eiwitten in de vloeibare fase , die zowel de geometrische structuur als de moleculaire massa-informatie van eiwitten.

Er werd een theorie ontwikkeld om de hydrodynamische straal van ionen en de verdeling van de ladingstoestand in het natieve massaspectrum te correleren met geometrische eiwitparameters, waardoor een lage-resolutiestructuur (vorm) van het eiwit kon worden bepaald. Onze testgegevens van 11 verschillende globulaire eiwitten toonden aan dat deze benadering ons in staat stelt om de vormen van individuele eiwitten, eiwitcomplexen en eiwitten in een mengsel te bepalen en om veranderingen in eiwitconformatie te volgen. Naast het verstrekken van aanvullende informatie over de eiwitstructuur en het vermogen om mengsels te analyseren, is deze op MCE en native MS gebaseerde methode snel in snelheid en laag in monsterconsumptie, waardoor deze mogelijk toepasbaar is in top-down proteomics en structurele biologie voor intacte globulaire eiwit- of eiwitcomplexanalyse.

Pim-2 Oncogene (PIM2) Polyclonal Antibody
CAU21186-100ul	Biomatik Corporation	100ul	EUR 265.9

Pim-2 Oncogene (PIM2) Polyclonal Antibody
CAU21186-200ul	Biomatik Corporation	200ul	EUR 332.6

Pim-2 Oncogene (PIM2) Polyclonal Antibody
CAU21187-100ul	Biomatik Corporation	100ul	EUR 259.2

Pim-2 Oncogene (PIM2) Polyclonal Antibody
CAU21187-200ul	Biomatik Corporation	200ul	EUR 324.2

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat)
4-PAP797Ra01	Cloud-Clone	EUR 330.00 EUR 3549.60 EUR 872.40 EUR 420.00 EUR 271.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2)

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human)
4-PAP797Hu01	Cloud-Clone	EUR 314.40 EUR 3296.40 EUR 814.80 EUR 397.20 EUR 264.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2)

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse)
4-PAP797Mu01	Cloud-Clone	EUR 319.20 EUR 3375.60 EUR 832.80 EUR 404.40 EUR 266.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2)

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), PE
4-PAP797Ra01-PE	Cloud-Clone	EUR 396.00 EUR 3754.80 EUR 1046.40 EUR 504.00 EUR 252.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with PE.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), APC
4-PAP797Ra01-APC	Cloud-Clone	EUR 465.60 EUR 4664.40 EUR 1278.00 EUR 601.20 EUR 284.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with APC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), Cy3
4-PAP797Ra01-Cy3	Cloud-Clone	EUR 571.20 EUR 6169.20 EUR 1654.80 EUR 751.20 EUR 330.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with Cy3.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), HRP
4-PAP797Ra01-HRP	Cloud-Clone	EUR 423.60 EUR 4062.00 EUR 1128.00 EUR 541.20 EUR 266.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with HRP.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), PE
4-PAP797Hu01-PE	Cloud-Clone	EUR 376.80 EUR 3478.80 EUR 976.80 EUR 476.40 EUR 243.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with PE.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), PE
4-PAP797Mu01-PE	Cloud-Clone	EUR 382.80 EUR 3565.20 EUR 998.40 EUR 486.00 EUR 246.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with PE.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), FITC
4-PAP797Ra01-FITC	Cloud-Clone	EUR 396.00 EUR 3754.80 EUR 1046.40 EUR 504.00 EUR 252.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with FITC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), APC
4-PAP797Hu01-APC	Cloud-Clone	EUR 441.60 EUR 4318.80 EUR 1191.60 EUR 566.40 EUR 274.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with APC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), Cy3
4-PAP797Hu01-Cy3	Cloud-Clone	EUR 538.80 EUR 5708.40 EUR 1539.60 EUR 705.60 EUR 316.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with Cy3.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), HRP
4-PAP797Hu01-HRP	Cloud-Clone	EUR 402.00 EUR 3762.00 EUR 1052.40 EUR 511.20 EUR 258.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with HRP.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), APC
4-PAP797Mu01-APC	Cloud-Clone	EUR 448.80 EUR 4426.80 EUR 1219.20 EUR 577.20 EUR 278.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with APC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), Cy3
4-PAP797Mu01-Cy3	Cloud-Clone	EUR 548.40 EUR 5852.40 EUR 1575.60 EUR 720.00 EUR 320.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with Cy3.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), HRP
4-PAP797Mu01-HRP	Cloud-Clone	EUR 409.20 EUR 3855.60 EUR 1076.40 EUR 519.60 EUR 260.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with HRP.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), FITC
4-PAP797Hu01-FITC	Cloud-Clone	EUR 376.80 EUR 3478.80 EUR 976.80 EUR 476.40 EUR 243.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with FITC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), FITC
4-PAP797Mu01-FITC	Cloud-Clone	EUR 382.80 EUR 3565.20 EUR 998.40 EUR 486.00 EUR 246.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with FITC.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), Biotinylated
4-PAP797Ra01-Biotin	Cloud-Clone	EUR 411.60 EUR 3489.60 EUR 1006.80 EUR 510.00 EUR 278.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with Biotin.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), Biotinylated
4-PAP797Hu01-Biotin	Cloud-Clone	EUR 393.60 EUR 3236.40 EUR 943.20 EUR 484.80 EUR 271.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with Biotin.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), Biotinylated
4-PAP797Mu01-Biotin	Cloud-Clone	EUR 398.40 EUR 3315.60 EUR 963.60 EUR 493.20 EUR 273.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with Biotin.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Rat), APC-Cy7
4-PAP797Ra01-APC-Cy7	Cloud-Clone	EUR 788.40 EUR 9184.80 EUR 2413.20 EUR 1058.40 EUR 426.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-2 Oncogene (PIM2). This antibody is labeled with APC-Cy7.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Human), APC-Cy7
4-PAP797Hu01-APC-Cy7	Cloud-Clone	EUR 739.20 EUR 8493.60 EUR 2240.40 EUR 988.80 EUR 405.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-2 Oncogene (PIM2). This antibody is labeled with APC-Cy7.

Pim-2 Oncogene (PIM2) Polyclonal Antibody (Mouse), APC-Cy7
4-PAP797Mu01-APC-Cy7	Cloud-Clone	EUR 753.60 EUR 8709.60 EUR 2294.40 EUR 1010.40 EUR 412.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-2 Oncogene (PIM2). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody
CAU24100-100ul	Biomatik Corporation	100ul	EUR 255.4

Pim-1 Oncogene (PIM1) Polyclonal Antibody
CAU24100-200ul	Biomatik Corporation	200ul	EUR 319.2

Pim-1 Oncogene (PIM1) Polyclonal Antibody
CAU24101-100ul	Biomatik Corporation	100ul	EUR 241.9

Pim-1 Oncogene (PIM1) Polyclonal Antibody
CAU24101-200ul	Biomatik Corporation	200ul	EUR 302.4

Pim-1 Oncogene (PIM1) Polyclonal Antibody
CAU24102-100ul	Biomatik Corporation	100ul	EUR 235.2

Pim-1 Oncogene (PIM1) Polyclonal Antibody
CAU24102-200ul	Biomatik Corporation	200ul	EUR 294

Pim-3 Oncogene (PIM3) Polyclonal Antibody
CAU21250-100ul	Biomatik Corporation	100ul	EUR 259.2

Pim-3 Oncogene (PIM3) Polyclonal Antibody
CAU21250-200ul	Biomatik Corporation	200ul	EUR 324.2

Pim-2 Oncogene (PIM2) Antibody
abx236456-100ug	Abbexa	100 ug	EUR 661.2

Pim-2 Oncogene (PIM2) Antibody
20-abx174067	Abbexa	EUR 1111.20 EUR 560.40	1 mg 200 ug

Pim-2 Oncogene (PIM2) Antibody
20-abx101236	Abbexa	EUR 560.40 EUR 159.60 EUR 1612.80 EUR 760.80 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-2 Oncogene (PIM2) Antibody
20-abx101237	Abbexa	EUR 577.20 EUR 159.60 EUR 1696.80 EUR 794.40 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-2 Oncogene (PIM2) Antibody
20-abx129066	Abbexa	EUR 543.60 EUR 159.60 EUR 1579.20 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-2 Oncogene (PIM2) Antibody
abx431508-200ul	Abbexa	200 ul	EUR 460.8

Pim-2 Oncogene (PIM2) Antibody
abx433133-200ul	Abbexa	200 ul	EUR 460.8

Pim-2 Oncogene (PIM2) Antibody
abx433134-200ul	Abbexa	200 ul	EUR 460.8

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat)
4-PAC578Ra01	Cloud-Clone	EUR 310.80 EUR 3249.60 EUR 804.00 EUR 393.60 EUR 262.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1)

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse)
4-PAC578Mu01	Cloud-Clone	EUR 301.20 EUR 3091.20 EUR 768.00 EUR 379.20 EUR 258.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1)

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human)
4-PAN637Hu01	Cloud-Clone	EUR 314.40 EUR 3296.40 EUR 814.80 EUR 397.20 EUR 264.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3)

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), PE
4-PAC578Ra01-PE	Cloud-Clone	EUR 373.20 EUR 3427.20 EUR 964.80 EUR 471.60 EUR 242.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), APC
4-PAC578Ra01-APC	Cloud-Clone	EUR 436.80 EUR 4254.00 EUR 1176.00 EUR 560.40 EUR 272.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), Cy3
4-PAC578Ra01-Cy3	Cloud-Clone	EUR 532.80 EUR 5622.00 EUR 1518.00 EUR 697.20 EUR 313.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), HRP
4-PAC578Ra01-HRP	Cloud-Clone	EUR 398.40 EUR 3706.80 EUR 1039.20 EUR 505.20 EUR 255.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), PE
4-PAC578Mu01-PE	Cloud-Clone	EUR 361.20 EUR 3254.40 EUR 921.60 EUR 454.80 EUR 236.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), FITC
4-PAC578Ra01-FITC	Cloud-Clone	EUR 373.20 EUR 3427.20 EUR 964.80 EUR 471.60 EUR 242.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), PE
4-PAN637Hu01-PE	Cloud-Clone	EUR 376.80 EUR 3478.80 EUR 976.80 EUR 476.40 EUR 243.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), APC
4-PAC578Mu01-APC	Cloud-Clone	EUR 421.20 EUR 4038.00 EUR 1122.00 EUR 538.80 EUR 266.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with APC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), Cy3
4-PAC578Mu01-Cy3	Cloud-Clone	EUR 512.40 EUR 5334.00 EUR 1446.00 EUR 668.40 EUR 304.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), HRP
4-PAC578Mu01-HRP	Cloud-Clone	EUR 385.20 EUR 3519.60 EUR 992.40 EUR 486.00 EUR 250.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), APC
4-PAN637Hu01-APC	Cloud-Clone	EUR 441.60 EUR 4318.80 EUR 1191.60 EUR 566.40 EUR 274.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with APC.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), Cy3
4-PAN637Hu01-Cy3	Cloud-Clone	EUR 538.80 EUR 5708.40 EUR 1539.60 EUR 705.60 EUR 316.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with Cy3.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), HRP
4-PAN637Hu01-HRP	Cloud-Clone	EUR 402.00 EUR 3762.00 EUR 1052.40 EUR 511.20 EUR 258.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with HRP.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), FITC
4-PAC578Mu01-FITC	Cloud-Clone	EUR 361.20 EUR 3254.40 EUR 921.60 EUR 454.80 EUR 236.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), FITC
4-PAN637Hu01-FITC	Cloud-Clone	EUR 376.80 EUR 3478.80 EUR 976.80 EUR 476.40 EUR 243.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with FITC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), APC-Cy7
4-PAC578Ra01-APC-Cy7	Cloud-Clone	EUR 729.60 EUR 8364.00 EUR 2208.00 EUR 976.80 EUR 402.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Rat), Biotinylated
4-PAC578Ra01-Biotin	Cloud-Clone	EUR 390.00 EUR 3189.60 EUR 932.40 EUR 480.00 EUR 270.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat)
4-PAC578Hu01	Cloud-Clone	EUR 296.40 EUR 3012.00 EUR 750.00 EUR 372.00 EUR 256.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1)

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), APC-Cy7
4-PAC578Mu01-APC-Cy7	Cloud-Clone	EUR 699.60 EUR 7932.00 EUR 2100.00 EUR 933.60 EUR 388.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), APC-Cy7
4-PAN637Hu01-APC-Cy7	Cloud-Clone	EUR 739.20 EUR 8493.60 EUR 2240.40 EUR 988.80 EUR 405.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Mouse), Biotinylated
4-PAC578Mu01-Biotin	Cloud-Clone	EUR 379.20 EUR 3031.20 EUR 892.80 EUR 464.40 EUR 265.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.

Pim-3 Oncogene (PIM3) Polyclonal Antibody (Human), Biotinylated
4-PAN637Hu01-Biotin	Cloud-Clone	EUR 393.60 EUR 3236.40 EUR 943.20 EUR 484.80 EUR 271.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Pim-3 Oncogene (PIM3). This antibody is labeled with Biotin.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), PE
4-PAC578Hu01-PE	Cloud-Clone	EUR 355.20 EUR 3168.00 EUR 900.00 EUR 446.40 EUR 234.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with PE.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), APC
4-PAC578Hu01-APC	Cloud-Clone	EUR 414.00 EUR 3930.00 EUR 1094.40 EUR 528.00 EUR 262.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), Cy3
4-PAC578Hu01-Cy3	Cloud-Clone	EUR 502.80 EUR 5190.00 EUR 1410.00 EUR 654.00 EUR 301.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Cy3.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), HRP
4-PAC578Hu01-HRP	Cloud-Clone	EUR 379.20 EUR 3426.00 EUR 968.40 EUR 477.60 EUR 247.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with HRP.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), FITC
4-PAC578Hu01-FITC	Cloud-Clone	EUR 355.20 EUR 3168.00 EUR 900.00 EUR 446.40 EUR 234.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with FITC.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), APC-Cy7
4-PAC578Hu01-APC-Cy7	Cloud-Clone	EUR 685.20 EUR 7716.00 EUR 2046.00 EUR 912.00 EUR 382.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with APC-Cy7.

Pim-1 Oncogene (PIM1) Polyclonal Antibody (Human, Mouse, Rat), Biotinylated
4-PAC578Hu01-Biotin	Cloud-Clone	EUR 373.20 EUR 2952.00 EUR 872.40 EUR 457.20 EUR 262.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat Pim-1 Oncogene (PIM1). This antibody is labeled with Biotin.

Recombinant Pim-2 Oncogene (PIM2)
4-RPP797Hu01	Cloud-Clone	EUR 528.58 EUR 265.20 EUR 1652.16 EUR 630.72 EUR 1141.44 EUR 429.60 EUR 3950.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Pim-2 Oncogene expressed in: E.coli

Recombinant Pim-2 Oncogene (PIM2)
4-RPP797Mu01	Cloud-Clone	EUR 560.83 EUR 273.60 EUR 1773.12 EUR 671.04 EUR 1222.08 EUR 451.20 EUR 4252.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Pim-2 Oncogene expressed in: E.coli

Recombinant Pim-2 Oncogene (PIM2)
4-RPP797Ra01	Cloud-Clone	EUR 582.34 EUR 279.60 EUR 1853.76 EUR 697.92 EUR 1275.84 EUR 465.60 EUR 4454.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Pim-2 Oncogene expressed in: E.coli

Recombinant Pim-2 Oncogene (PIM2)
RPU51241-100ug	Biomatik Corporation	100ug	EUR 468.6

Recombinant Pim-2 Oncogene (PIM2)
RPU51241-1mg	Biomatik Corporation	1mg	EUR 2074.8

Recombinant Pim-2 Oncogene (PIM2)
RPU51241-50ug	Biomatik Corporation	50ug	EUR 376.2

Recombinant Pim-2 Oncogene (PIM2)
RPU43301-100ug	Biomatik Corporation	100ug	EUR 504.9

Recombinant Pim-2 Oncogene (PIM2)
RPU43301-1mg	Biomatik Corporation	1mg	EUR 2238.6

Recombinant Pim-2 Oncogene (PIM2)
RPU43301-50ug	Biomatik Corporation	50ug	EUR 405.9

Recombinant Pim-2 Oncogene (PIM2)
RPU43302-100ug	Biomatik Corporation	100ug	EUR 530.2

Recombinant Pim-2 Oncogene (PIM2)
RPU43302-1mg	Biomatik Corporation	1mg	EUR 2347.8

Recombinant Pim-2 Oncogene (PIM2)
RPU43302-50ug	Biomatik Corporation	50ug	EUR 425.7

Rat Pim-2 Oncogene (PIM2) Protein
20-abx068550	Abbexa	EUR 811.20 EUR 343.20 EUR 2498.40 EUR 961.20 EUR 577.20	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Pim-2 Oncogene (PIM2) Protein
20-abx068549	Abbexa	EUR 777.60 EUR 326.40 EUR 2397.60 EUR 927.60 EUR 560.40	100 ug 10 ug 1 mg 200 ug 50 ug

Human Pim-2 Oncogene (PIM2) Protein
20-abx168058	Abbexa	EUR 744.00 EUR 326.40 EUR 2230.80 EUR 878.40 EUR 543.60	100 ug 10 ug 1 mg 200 ug 50 ug

Rat Pim-2 Oncogene(PIM2))ELISA Kit
QY-E10538	Qayee Biotechnology	96T	EUR 480

Human Pim-2 Oncogene (PIM2) CLIA Kit
20-abx190021	Abbexa	EUR 9493.20 EUR 5058.00 EUR 1167.60	10 × 96 tests 5 × 96 tests 96 tests

Human Pim-2 Oncogene (PIM2)CLIA Kit
SCP797Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2)CLIA Kit
SCP797Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2)CLIA Kit
SCP797Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2)CLIA Kit
SCP797Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) CLIA Kit
4-SCP797Hu	Cloud-Clone	EUR 6837.60 EUR 3673.20 EUR 896.40	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Pim-2 Oncogene (PIM2)Serum, plasma, tissue homogenates and other biological fluids

Human Pim-2 Oncogene (PIM2) CLIA Kit
EKU09423-48T	Biomatik Corporation	48T	EUR 666.82

Human Pim-2 Oncogene (PIM2) CLIA Kit
EKU09423-5x96T	Biomatik Corporation	5x96T	EUR 4524.85

Human Pim-2 Oncogene (PIM2) CLIA Kit
EKU09423-96T	Biomatik Corporation	96T	EUR 952.6

Human Pim-2 Oncogene (PIM2) CLIA Kit
EKN50534-48T	Biomatik Corporation	48T	EUR 414.89

Human Pim-2 Oncogene (PIM2) CLIA Kit
EKN50534-5x96T	Biomatik Corporation	5x96T	EUR 2815.33

Human Pim-2 Oncogene (PIM2) CLIA Kit
EKN50534-96T	Biomatik Corporation	96T	EUR 592.7

Human Pim-2 Oncogene (PIM2) ELISA Kit
201-12-2346	SunredBio	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
DLR-PIM2-Hu-48T	DL Develop	48T	EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Pim-2 Oncogene (PIM2) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
DLR-PIM2-Hu-96T	DL Develop	96T	EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Pim-2 Oncogene (PIM2) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
20-abx152745	Abbexa	EUR 8853.60 EUR 4719.60 EUR 1093.20	10 × 96 tests 5 × 96 tests 96 tests

Human Pim-2 Oncogene (PIM2) ELISA Kit
SEP797Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
SEP797Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
SEP797Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
SEP797Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Pim-2 Oncogene (PIM2) in serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
4-SEP797Hu	Cloud-Clone	EUR 6288.00 EUR 3322.80 EUR 831.60	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Pim-2 Oncogene (PIM2) in samples from Serum, plasma, tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Pim-2 Oncogene (PIM2) ELISA Kit
RD-PIM2-Hu-48Tests	Reddot Biotech	48 Tests	EUR 675.6

Human Pim-2 Oncogene (PIM2) ELISA Kit
RD-PIM2-Hu-96Tests	Reddot Biotech	96 Tests	EUR 939.6

Human Pim-2 Oncogene (PIM2) ELISA Kit
RDR-PIM2-Hu-48Tests	Reddot Biotech	48 Tests	EUR 706.8

Human Pim-2 Oncogene (PIM2) ELISA Kit
RDR-PIM2-Hu-96Tests	Reddot Biotech	96 Tests	EUR 984

Mouse Pim-2 Oncogene(PIM2))ELISA Kit
QY-E21185	Qayee Biotechnology	96T	EUR 433.2

Human Pim-2 Oncogene (PIM2) ELISA Kit
RDR-PIM2-Hu-48T	Reddot Biotech	48T	EUR 518.18
Description: serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
RDR-PIM2-Hu-96T	Reddot Biotech	96T	EUR 740.25
Description: serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
RD-PIM2-Hu-48T	Reddot Biotech	48T	EUR 493.5
Description: serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
RD-PIM2-Hu-96T	Reddot Biotech	96T	EUR 705
Description: serum, plasma, tissue homogenates and other biological fluids.

Human Pim-2 Oncogene(PIM2)ELISA Kit
QY-E04697	Qayee Biotechnology	96T	EUR 433.2

Human Pim-2 Oncogene (PIM2) ELISA Kit
DL-PIM2-Hu	DL Develop	96T	EUR 481
Description: serum, plasma, tissue homogenates or other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
DLR-PIM2-Hu	DL Develop	96T	EUR 505
Description: serum, plasma, tissue homogenates or other biological fluids.

Human Pim-2 Oncogene (PIM2) ELISA Kit
YLA3057HU-48T	Shanghai YL Biotech	48T	EUR 435

Human Pim-2 Oncogene (PIM2) ELISA Kit
YLA3057HU-96T	Shanghai YL Biotech	96T	EUR 562.5

Human Pim-2 Oncogene (PIM2) ELISA Kit
EKN47753-48T	Biomatik Corporation	48T	EUR 416.29

Human Pim-2 Oncogene (PIM2) ELISA Kit
EKN47753-5x96T	Biomatik Corporation	5x96T	EUR 2824.83

Human Pim-2 Oncogene (PIM2) ELISA Kit
EKN47753-96T	Biomatik Corporation	96T	EUR 594.7

Human Pim-2 Oncogene (PIM2) ELISA Kit
EKU06642-48T	Biomatik Corporation	48T	EUR 610.82

Human Pim-2 Oncogene (PIM2) ELISA Kit
EKU06642-5x96T	Biomatik Corporation	5x96T	EUR 4144.85

Human Pim-2 Oncogene (PIM2) ELISA Kit
EKU06642-96T	Biomatik Corporation	96T	EUR 872.6

Human PIM2(Pim-2 Oncogene) ELISA Kit
ELK6492-48T	ELK Biotech	48T	Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PIM2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PIM2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PIM2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PIM2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human PIM2(Pim-2 Oncogene) ELISA Kit
ELK6492-96T	ELK Biotech	96T	Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PIM2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PIM2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PIM2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PIM2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Pim-1 Oncogene (PIM1) Antibody
20-abx174066	Abbexa	EUR 1028.40 EUR 526.80	1 mg 200 ug

Pim-3 Oncogene (PIM3) Antibody
20-abx174068	Abbexa	EUR 1111.20 EUR 560.40	1 mg 200 ug

Pim-1 Oncogene (PIM1) Antibody
abx146417-100ug	Abbexa	100 ug	EUR 469.2

Pim-1 Oncogene (PIM1) Antibody
20-abx101233	Abbexa	EUR 510.00 EUR 159.60 EUR 1446.00 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-1 Oncogene (PIM1) Antibody
20-abx101234	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-1 Oncogene (PIM1) Antibody
20-abx101235	Abbexa	EUR 543.60 EUR 159.60 EUR 1562.40 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-3 Oncogene (PIM3) Antibody
20-abx131576	Abbexa	EUR 543.60 EUR 159.60 EUR 1579.20 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-2 Oncogene (PIM2) Magnetic Luminex Assay Kit
LKU606918-96T	Biomatik Corporation	96T	EUR 1062.6

ELISA kit for Human PIM2 (Pim-2 Oncogene)
ELK6492	ELK Biotech	1 plate of 96 wells	EUR 518.4
Description: A sandwich ELISA kit for detection of Pim-2 Oncogene from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Pim-1 Oncogene (PIM1) Antibody (Biotin)
20-abx271779	Abbexa	EUR 543.60 EUR 292.80 EUR 1579.20 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-1 Oncogene (PIM1) Antibody (Biotin)
20-abx272590	Abbexa	EUR 560.40 EUR 292.80 EUR 1612.80 EUR 760.80 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Pim-1 Oncogene (PIM1) Antibody (Biotin)
20-abx273089	Abbexa	EUR 577.20 EUR 292.80 EUR 1696.80 EUR 794.40 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Rabbit Pim 1 Oncogene ELISA kit
E04P0753-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Pim 1 Oncogene ELISA kit
E04P0753-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Pim 1 Oncogene ELISA kit
E04P0753-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Pim 1 Oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Pim-3 Oncogene (PIM3)
4-RPN637Hu01	Cloud-Clone	EUR 560.83 EUR 273.60 EUR 1773.12 EUR 671.04 EUR 1222.08 EUR 451.20 EUR 4252.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Pim-3 Oncogene expressed in: E.coli

Recombinant Pim-1 Oncogene (PIM1)
4-RPC578Hu01	Cloud-Clone	EUR 560.83 EUR 273.60 EUR 1773.12 EUR 671.04 EUR 1222.08 EUR 451.20 EUR 4252.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Pim-1 Oncogene expressed in: E.coli

Recombinant Pim-1 Oncogene (PIM1)
4-RPC578Mu01	Cloud-Clone	EUR 571.58 EUR 276.00 EUR 1813.44 EUR 684.48 EUR 1248.96 EUR 458.40 EUR 4353.60	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Pim-1 Oncogene expressed in: E.coli

Recombinant Pim-1 Oncogene (PIM1)
4-RPC578Ra01	Cloud-Clone	EUR 560.83 EUR 273.60 EUR 1773.12 EUR 671.04 EUR 1222.08 EUR 451.20 EUR 4252.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Pim-1 Oncogene expressed in: E.coli

Recombinant Pim-3 Oncogene (PIM3)
RPU51923-100ug	Biomatik Corporation	100ug	EUR 504.9

Recombinant Pim-3 Oncogene (PIM3)
RPU51923-1mg	Biomatik Corporation	1mg	EUR 2238.6

Recombinant Pim-3 Oncogene (PIM3)
RPU51923-50ug	Biomatik Corporation	50ug	EUR 405.9

Recombinant Pim-1 Oncogene (PIM1)
RPU43298-100ug	Biomatik Corporation	100ug	EUR 504.9

Recombinant Pim-1 Oncogene (PIM1)
RPU43298-1mg	Biomatik Corporation	1mg	EUR 2238.6

Recombinant Pim-1 Oncogene (PIM1)
RPU43298-50ug	Biomatik Corporation	50ug	EUR 405.9

Recombinant Pim-1 Oncogene (PIM1)
RPU43299-100ug	Biomatik Corporation	100ug	EUR 504.9

Recombinant Pim-1 Oncogene (PIM1)
RPU43299-1mg	Biomatik Corporation	1mg	EUR 2238.6

Recombinant Pim-1 Oncogene (PIM1)
RPU43299-50ug	Biomatik Corporation	50ug	EUR 405.9

Recombinant Pim-1 Oncogene (PIM1)
RPU43300-100ug	Biomatik Corporation	100ug	EUR 517

Recombinant Pim-1 Oncogene (PIM1)
RPU43300-1mg	Biomatik Corporation	1mg	EUR 2293.2

Snelle oppervlakte-immobilisatie van natieve  eiwitten  door katalysatorvrije amino-yn-klik-bioconjugatie

Oppervlakte-immobilisatie biedt een nuttig platform voor biosensing, screening van geneesmiddelen, weefselengineering en andere chemische en biologische toepassingen. Echter , sommige van de gebruikte reacties zijn inefficiënt en / of ingewikkeld, hun toepassingen te beperken in immobilisatie. Hierin gebruiken we een spontane en katalysatorvrije amino-yn-klik bioconjugatie om geactiveerde met ethynylgroep gefunctionaliseerde oppervlakken te genereren voor snelle immobilisatie van inheemse eiwitten en cellen.

Biomoleculen, zoals runderserumalbumine (BSA) , humaan IgG en een peptide van C(RGDfK), konden in slechts 30 minuten covalent op de oppervlakken worden geïmmobiliseerd. Met identify de biologische activiteit van de verankerde biomoleculen blijft intact, wat wordt geverifieerd door het efficiënt vastleggen van doelantilichamen en cellen uit de bulkoplossingen. Deze strategie vertegenwoordigt een alternatief voor zeer efficiënte biofunctionalisatie van het oppervlak.

Over de bindingsreactie van loratadine met humaan serum acute fase-  eiwit  alfa-1-zuur glyco- eiwit

Loratadine is een belangrijk anti-allergisch medicijn. Het is een antihistaminicum van de tweede generatie dat wordt gebruikt voor de behandeling van allergische rhinitis, hooikoorts en urticaria. Humaan alfa-1-zuur-glycoproteïne (AG) in serum is een belangrijk eiwit in de acute fase en de serumconcentratie ervan blijkt te stijgen bij ontsteking en acute respons. De bindingsinteractie tussen loratadine en AG wordt bestudeerd met behulp van spectroscopie en moleculaire koppeltechnieken. De resultaten verkregen uit fluorescentie- uitdovingsexperimenten toonden aan dat de fluorescentie-intensiteit van AG wordt gedoofd door loratadine. Loratadine bleek AG binden aan de bindingsconstante van ≈10 ⁴  bij 298 Okay.

De vrije energieverandering van Gibb bleek negatief te zijn voor de interactie van loratadine met AG, wat aangeeft dat het bindingsproces spontaan is. Binding van loratadine met AG induceerde geordende structuren in het eiwit. Waterstofbinding en hydrofobe interacties waren de belangrijkste bindingskrachten tussen AG-loratadine, zoals blijkt uit moleculaire koppelingsresultaten. Deze studie suggereert het belang van het ruimtelijk binden van anti-allergische geneesmiddelen aan AG bij ziekten waarbij de plasmaconcentratie van AG vele malen toeneemt en interactie met dit eiwit vital wordt. Deze studie zal helpen bij het ontwerpen van de medicijndosering en dienovereenkomstige aanpassing om een ​​optimaal behandelresultaat te bereiken. Gecommuniceerd door Ramaswamy H. Sarma.

Gerichte  Protein  Degradatie door middel van Quick optogenetische Activering en de toepassing ervan op de beheersing van de Cell Signaling

De ontwikkeling van methodologieën voor optisch getriggerde eiwitafbraak maakt de studie mogelijk van dynamische eiwitfuncties, zoals die welke betrokken zijn bij celsignalering , die moeilijk te onderzoeken zijn met traditionele genetische technieken. Hier beschrijven we het ontwerp en de implementatie van een nieuw lichtgecontroleerd peptide-degron dat N-end-pathway-degradatie aan zijn eiwitdoelwit verleent. De degron omvat een fotogekooid N-terminaal aminozuur en een lysinerijke linker met 13 residu’s. Door het N-terminale residu te kooien , waren we in staat om de herkenning van N-degron door een E3-ligase optisch te regelen, waardoor de ubiquitinatie en proteasomale afbraak van het doeleiwit werd gecontroleerd.

We demonstreren brede toepasbaarheid door deze benadering toe te passen op een various reeks doeleiwitten, waaronder EGFP, vuurvliegluciferase, de kinase MEK1 en de fosfatase DUSP6 (ook bekend als MKP3). De gekooide degron kan worden gebruikt met minimale eiwittechnologie en biedt vrijwel volledige, door licht geactiveerde eiwitafbraak op een tijdschaal van seconden tot minuut.